ARL4C Antibody

中文名稱：

ARL4C兔多克隆抗體
貨號：

CSB-PA002086LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA002086LA01HU at dilution of 1:100

Immunofluorescence staining of PC-3 cells with CSB-PA002086LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ARL4C Polyclonal antibody
Uniprot No.：

P56559
基因名：

ARL4C
別名：

ADP ribosylation factor like 4C antibody; ADP ribosylation factor like 7 antibody; ADP-ribosylation factor-like protein 4C antibody; ADP-ribosylation factor-like protein 7 antibody; ADP-ribosylation factor-like protein LAK antibody; Arl4c antibody; ARL4C_HUMAN antibody; ARL7 antibody; LAK antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ADP-ribosylation factor-like protein 4C protein (2-192AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ARL4C Antibody (CSB-PA002086LA01HU)，的標記方式是Non-conjugated。對于ARL4C Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA002086LB01HU	ARL4C Antibody, HRP conjugated	ELISA
FITC	CSB-PA002086LC01HU	ARL4C Antibody, FITC conjugated
Biotin	CSB-PA002086LD01HU	ARL4C Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process.
基因功能參考文獻：
1. We demonstrate that ARL4C knockdown likely attenuates osteogenesis of hASCs through inhibition of the Wnt signaling pathway. These results provide new insights into the mechanisms of osteogenic differentiation and provide a potential molecular target for bone tissue engineering. PMID: 29432742
2. ARL4C is expressed due to hypomethylation in the 3'-UTR for certain types of cancers and that ARL4C methylation status is involved in squamous cell carcinoma cell function. PMID: 27835592
3. Arl4c as a novel Wnt signal target molecule that links epithelial tubulogenesis to tumourigenesis. PMID: 28053143
4. Results indicated that overexpression of Arl4c might contribute to the tumorigenesis and might play a pivotal role in the progression of CRC. PMID: 26756615
5. Arl4c is involved in tumorigenesis and might represent a novel therapeutic target for suppressing proliferation and invasion of colorectal and lung cancer cells. PMID: 25486429
6. Study shows that three related Arf-like GTPases Arl4a, Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form. PMID: 17398095
7. ARL7 might modulate the intracellular vesicular transport via interaction with microtubules. PMID: 19409876
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亞細胞定位：

Cell projection, filopodium. Cell membrane. Cytoplasm.
蛋白家族：

Small GTPase superfamily, Arf family
組織特異性：

Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta.
數據庫鏈接：

HGNC: 698

OMIM: 604787

KEGG: hsa:10123

STRING: 9606.ENSP00000375057

UniGene: Hs.111554

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