ARID3A Antibody
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中文名稱：ARID3A兔多克隆抗體
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貨號：CSB-PA002061GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：ARID3A
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別名：ARI3A_HUMAN antibody; ARID domain containing 3A antibody; ARID domain-containing protein 3A antibody; ARID3A antibody; AT rich interactive domain 3A (BRIGHT- like) protein antibody; AT rich interactive domain 3A (BRIGHT-like) antibody; AT rich interactive domain-containing protein 3A antibody; AT-rich interactive domain-containing protein 3A antibody; B cell regulator of IgH transcription antibody; B-cell regulator of IgH transcription antibody; Bright antibody; dead ringer like 1 antibody; dead ringer; Drosophila; homolog-like 1 antibody; Dead ringer-like protein 1 antibody; DRIL1 antibody; DRIL3 antibody; DRX antibody; E2F binding protein 1 antibody; E2F-binding protein 1 antibody; E2FBP1 antibody; Homo sapiens AT rich interactive domain 3A (BRIGHT-like) antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human ARID3A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
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基因功能參考文獻：
- Data indicate ARID3a(+) B cells as a type of effector B cell, and link ARID3a expression in B lymphocytes to interferon alpha (IFNa)-associated inflammatory responses in systemic lupus erythematosus (SLE). PMID: 27522115
- results suggest that appropriate regulation of ARID3a is critical for normal development of both myeloid and B lineage pathways. PMID: 26685208
- These data reveal new functions for ARID3a in early hematopoiesis and suggest that knowledge regarding ARID3a levels in HSPCs could be informative for applications requiring transplantation of those cells. PMID: 25535283
- Systemic lupus erythematosus (SLE) patients had increased ARID3a+ B cells compared to healthy controls. ARID3a was not expressed in naive B cells of controls, but was abundant in SLE patients. Number of ARID3a+ B cells correlated with disease activity. PMID: 25185498
- miR-125b can act as an oncogene in B-cell acute lymphoblastic leukemia by targeting ARID3a and mediating its repression. PMID: 22469780
- These findings support the hypothesis that Epstein-Barr virus EBNA1 initiates transcription at the C promoter via interactions between multiple EBNA1 homodimers and cellular transcription such as E2F1, ARID3A and Oct-2. PMID: 22302879
- These results indicate both cooperative and interdependent roles for ARID3A and p53 in the transcriptional activation of p21(WAF1) in response to DNA damage. PMID: 22172947
- functions as a critical antagonist to the p16(INK4A)-Rb tumor suppressor machinery by regulating promyelocytic leukemia protein stability PMID: 22010578
- report that E2FBP1 inhibits accumulation of ICP0 RNA and, at the same time, is degraded via ICP0's herpes ubiquitin ligase 2 (HUL-2) activity upon HSV-1 infection. PMID: 21248039
- Bright/ARID3a inhibition causes increased developmental plasticity in mouse and human cells. PMID: 20680960
- Solution NMR structure of the ARID domain of human ARID3A. PMID: 20455271
- Results show that DRIL1 disrupts cellular protection against RAS(V12)-induced proliferation downstream of the p19(ARF)/p53 pathway. PMID: 11812999
- role in p53 regulatory pathway.(E2FBP1) PMID: 12136662
- Variations in Bright binding and matrix attachment region activity contribute to localized control of accessibility and therefore nonrandom gene use during V(D)J recombination. PMID: 12193717
- a putative p53-binding site was found, which specifically responded to p53, in the second intron of the E2FBP1/DRIL1 gene PMID: 12692263
- E2FBP1 modulates cell growth through down-regulation of promyelocytic leukemia bodies. PMID: 15017387
- Bright is not expressed in all human B lymphocyte subpopulations. PMID: 15203319
- TFII-I directly interacts with Bright through amino acids in Bright's protein interaction domain PMID: 16738337
- identify Bright as a contributor to accessibility of the IgH enhancer PMID: 17386101
- Id1 inhibited DNA binding by Dril1, and the two proteins co-localized in vitro and in vivo, providing a potential mechanism for suppression of fibrosis by Id1 through inhibition of the profibrotic function of Dril1. PMID: 18583319
- A palmitoylated pool of Bright is diverted to lipid rafts of resting B cells where it associates with signalosome components. PMID: 19214191
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亞細胞定位：Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
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組織特異性：Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.
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數據庫鏈接：
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