ARFRP1 Antibody

中文名稱：

ARFRP1兔多克隆抗體
貨號：

CSB-PA621696LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA621696LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ARFRP1 Polyclonal antibody
Uniprot No.：

Q13795
基因名：

ARFRP1
別名：

ADP ribosylation factor related protein 1 antibody; ADP-ribosylation factor-related protein 1 antibody; ARF related protein 1 antibody; ARF related protein antibody; ARF-related protein 1 antibody; ARFRP_HUMAN antibody; ARFRP1 antibody; ARL 18 antibody; ARL18 antibody; ARP 1 antibody; ARP antibody; ARP1 antibody; Helicase like protein NHL antibody; MGC6837 antibody; SCG10 like protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ADP-ribosylation factor-related protein 1 protein (1-201AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ARFRP1 Antibody (CSB-PA621696LA01HU)，的標記方式是Non-conjugated。對于ARFRP1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA621696LB01HU	ARFRP1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA621696LC01HU	ARFRP1 Antibody, FITC conjugated
Biotin	CSB-PA621696LD01HU	ARFRP1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.
基因功能參考文獻：
1. Results provide evidence that ARFRP1 is required for HCV propagation through its interaction with NS5A protein. Also, ARFRP1 is involved in the regulation of lipid droplet (LD) growth in HCV-infected cells and, recruits SNAP23 to sites in close proximity to LDs. PMID: 27550144
2. ARFRP1 shifted from a predominantly cis-Golgi and endosome-to-trans-Golgi network localization to localizing both Golgi and non-Golgi vesicular structures in hNaa30-depleted cells. PMID: 28356483
3. One or more of 7 genes residing in a chromosome 20q13.3 CNV region appears to influence BMI. The strongest candidate is ARFRP1. PMID: 26881067
4. Propose that Arfrp1 exposes a binding site on AP-1 that recognizes the Vangl2 sorting motif for capture into a transport vesicle destined for the proximal surface of a polarized epithelial cell. PMID: 23326640
5. The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. PMID: 22505585
6. Data show that ADP-ribosylation factor-related protein 1 (ARFRP1) is associated mainly with the trans-Golgi compartment and the trans-Golgi network (TGN) and is an essential regulatory factor for targeting of golgin-97 and golgin-245 onto Golgi membranes. PMID: 16129887
7. These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi. PMID: 17127620
8. Results show that ARL1 and ARFRP1 regulate retrograde transport of Shiga toxin to the TGN and anterograde transport of VSVG from the TGN, respectively. PMID: 19224922
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亞細胞定位：

Golgi apparatus. Golgi apparatus, trans-Golgi network.
蛋白家族：

Small GTPase superfamily, Arf family
組織特異性：

Found in most tissues.
數據庫鏈接：

HGNC: 662

OMIM: 604699

KEGG: hsa:10139

STRING: 9606.ENSP00000326884

UniGene: Hs.389277

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