ARAF Antibody
-
中文名稱：ARAF兔多克隆抗體
-
貨號：CSB-PA000918
-
規(guī)格：￥1090
-
圖片：
-
Western Blot analysis of HeLa cells using A-Raf Polyclonal Antibody
-
-
其他：
產(chǎn)品詳情
-
Uniprot No.：
-
基因名：
-
別名：A raf 1 antibody; A Raf proto oncogene serine/threonine protein kinase antibody; ARAF 1 antibody; Araf antibody; ARaf proto oncogene serine/threonine protein kinase antibody; ARAF_HUMAN antibody; ARAF1 antibody; Oncogene Araf1 antibody; Oncogene PKS2 antibody; PKS 2 antibody; PKS antibody; PKS2 antibody; Proto oncogene Pks antibody; Proto-oncogene A-Raf antibody; Proto-oncogene A-Raf-1 antibody; Proto-oncogene Pks antibody; RAFA 1 antibody; RAFA1 antibody; Ras binding protein DA Raf antibody; Serine/threonine-protein kinase A-Raf antibody; v raf murine sarcoma 3611 viral oncogene homolog antibody; v raf murine sarcoma 3611 viral oncogene homolog 1 antibody; v raf oncogene homolog 1 (murine sarcoma 3611 virus) antibody
-
宿主：Rabbit
-
反應(yīng)種屬：Human,Mouse,Rat
-
免疫原：Synthesized peptide derived from Human A-Raf around the non-phosphorylation site of Y302.
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Non-conjugated
-
抗體亞型：IgG
-
純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：WB, IHC, ELISA
-
推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
-
功能：Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.; Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
-
基因功能參考文獻：
- The constitutive or induced re-localization of A-Raf to the plasma membrane compromises its ability to efficiently sequester and inactivate MST2, thus rendering cells susceptible to apoptosis PMID: 26891695
- This review discusses the regulation of A-Raf protein expression, and the roles of A-Raf in apoptosis and cancer, with a special focus on its role in resistance to Raf inhibitors. [review] PMID: 26508523
- analysis of FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma PMID: 25608663
- Aberrant expression of A-, B-, and C-RAF, and COT is frequent in PTC; increased expression of COT is correlated with recurrence of PTC. PMID: 25674762
- Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration. PMID: 25097033
- The study identifies somatic activating ARAF mutations in Langerhans cell histiocytosis. PMID: 24652991
- Galpha12-ARAF-ERK pathway stimulates RFFL transcription through the transcription factor c-Myc. PMID: 24114843
- show that Araf antagonizes mesendoderm induction and patterning activity of Nodal/Smad2 signals in vertebrate embryos by directly inhibiting Smad2 signalling PMID: 23591895
- study investigated role of ARAF in cancer cell signaling and examined the role of ARAF in mediating paradoxical activation of the MAPK pathway in cells treated with RAF inhibitors; ARAF seems to stabilize BRAF:CRAF complexes in cells treated with RAF inhibitors and regulate cell signaling in a subtle manner to ensure signaling efficiency PMID: 22926515
- Ras pathway activation via EGF treatment induced strong binding between B-Raf and C-Raf and a low level of binding between B-Raf and A-Raf. PMID: 23352452
- hnRNP H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. PMID: 20145135
- In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf. PMID: 11952167
- A-Raf kinase is negatively regulated by trihydrophobin 1 PMID: 14684750
- mutation analysis of the conserved regions in the ARAF gene in human colorectal adenocarcinoma PMID: 14688025
- A-Raf residues are identified that bind to specific phosphoinositides, possibly as a mechanism to localize the enzyme to particular membrane microdomains rich in these phospholipids. PMID: 15736953
- These data reveal that B-RAF is an important mediator of neuronal survival, migration, and dendrite formation and that A-RAF cannot fully compensate for these functions. PMID: 16980614
- Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites. PMID: 18662992
- A-Raf interacts with MEK1 and activates MEK1 by phosphorylation. PMID: 8621729
顯示更多
收起更多
-
蛋白家族：Protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily
-
組織特異性：Predominantly in urogenital tissues.
-
數(shù)據(jù)庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
