APOBEC1 Antibody

中文名稱：

APOBEC1兔多克隆抗體
貨號：

CSB-PA001919LA01HU
規格：

￥440
圖片：
Immunofluorescence staining of HepG2 cells with CSB-PA001919LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) APOBEC1 Polyclonal antibody
Uniprot No.：

P41238
基因名：

APOBEC1
別名：

ABEC1_HUMAN antibody; APOBEC 1 antibody; APOBEC1 antibody; Apolipoprotein B mRNA editing enzyme antibody; Apolipoprotein B mRNA editing enzyme catalytic polypeptide 1 antibody; Apolipoprotein B mRNA editing enzyme complex 1 antibody; Apolipoprotein B mRNA-editing enzyme 1 antibody; BEDP antibody; C->U-editing enzyme APOBEC-1 antibody; CDAR1 antibody; EC 3.5.4. antibody; HEPR antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human C->U-editing enzyme APOBEC-1 protein (1-172AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，APOBEC1 Antibody (CSB-PA001919LA01HU)，的標記方式是Non-conjugated。對于APOBEC1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA001919LB01HU	APOBEC1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001919LC01HU	APOBEC1 Antibody, FITC conjugated
Biotin	CSB-PA001919LD01HU	APOBEC1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
基因功能參考文獻：
1. Our findings propose APOBEC1 and isoform b as the potential endogenous mutators implicated in cancer in-frame indels and pave the way for their use as novel prognostic tumor markers. PMID: 29346513
2. Luciferase-fused 3' untranslated region of human Dickkopf1 activity was highly upregulated in A1CF-overexpressed MCF7 cells, but this upregulation can be inhibited by mutating conserved binding motifs of Dickkopf1 3' untranslated region. A1CF played a crucial role in cell migration and survival through affecting 3' untranslated region of Dickkopf1 to upregulate its expression in MCF7 cells. PMID: 28639893
3. AICDA/APOBEC family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. (Review) PMID: 26398702
4. Results show that expression of APOBEC1 induces a mutator phenotype in 2 different cellular models. PMID: 25085003
5. An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in esophageal squamous cell carcinoma. PMID: 25839328
6. hnRNPQ6 is required for APOBEC1-enhanced IL8 production. PMID: 25100733
7. Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4). PMID: 19911124
8. The hypermutation activity of APOBEC-1 was decreased to background levels by a single point APOBEC-1 mutation of P29F or E181Q, while 50% of wild-type control editing at the normal site was retained. PMID: 20348446
9. The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 with ACF might be operational during enterocyte differentiation. PMID: 19932086
10. expression of two proteins essential for apolipoprotein B mRNA editing from a single gene through alternative splicing PMID: 11815617
11. determination of multifunctional cycle and suppression of nonsense-mediated decay PMID: 12881431
12. apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling PMID: 12896982
13. apobec-1-mediated apoB mRNA editing is regulated by BAG-4 PMID: 14559896
14. Expression of Apobec1 in HepG2 cells resulted in apoB mRNA editing, leading to decreased apoB100 abundance (to 6% of control) and the appearance of apoB48. PMID: 15979078
15. APOBEC3G is not a nucleo-cytoplasmic shuttling protein like APOBEC-1 and activation-induced cytidine deaminase PMID: 16999936
16. No evidence of association of APOBEC1 and PPARG with gallstone susceptibility was detected. PMID: 17696929
17. Demonstrates the presence of a 36-aa peptide (isoform 2) derived from this gene in adult small intestinal villi using immunocytochemical analysis. PMID: 9186903
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亞細胞定位：

Cytoplasm.
蛋白家族：

Cytidine and deoxycytidylate deaminase family
組織特異性：

Expressed exclusively in the small intestine.
數據庫鏈接：

HGNC: 604

OMIM: 600130

KEGG: hsa:339

STRING: 9606.ENSP00000229304

UniGene: Hs.560

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