APBA3 Antibody
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中文名稱：APBA3兔多克隆抗體
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貨號：CSB-PA080020
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：APBA3
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別名：Adapter protein X11gamma antibody; amyloid beta (A4) precursor protein binding; family A; member 3 antibody; Amyloid beta A4 precursor protein-binding family A member 3 antibody; Amyloid beta precursor protein binding; family A; member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein antibody; APBA3 antibody; APBA3_HUMAN antibody; lin 10 antibody; MGC:15815 antibody; Mint 3 antibody; Mint-3 antibody; Neuron specific X11L2 protein antibody; Neuron-specific X11L2 protein antibody; Neuronal Munc18 1 interacting protein 3 antibody; Neuronal Munc18-1-interacting protein 3 antibody; phosphotyrosine binding/interacting domain (PTB) bearing protein antibody; X11 like 2 protein 2 antibody; X11gamma antibody; X11L2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human X11γ.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN.
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基因功能參考文獻：
- Results suggest that NECAB3, a novel Mint3-binding protein, activates HIF-1 to promote normoxic glycolysis and tumorigenicity by forming a ternary complex with Mint3 and FIH-1. PMID: 26948053
- FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. PMID: 24867948
- Mints are necessary for activity-induced APP and PS1 trafficking and provide insight into the cellular fate of APP in endocytic pathways essential for Abeta production. PMID: 24742670
- Strict specificity for recruitment of the Mint3 adaptor by APP at the Golgi, a critical role for Tyr-682 (within the YENPTY motif) in Mint3 recruitment and export of APP from the Golgi, are demonstrated. PMID: 23965993
- These results indicate that all three amyloid beta protein precursor family members are capable of activating gene transcription via Mint3-Taz and Mint3-Yap. PMID: 21178287
- Two transcriptional coactivators, TAZ and YAP, functionally associate with amyloid precursor protein through Mint3 and form transcriptionally active triple protein complexes. PMID: 20016085
- Associated with etilogical mechanism of Alzheimer's disease. PMID: 11831025
- Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV PMID: 14990567
- We have examined the ability of Bcr to interact with other epithelial PDZ proteins and found specific binding to both the apical PDZK1 protein and the Golgi-localized Mint3 PMID: 15494376
- These data implicate Mint3 activity as a critical determinant of post-Golgi APP traffic. PMID: 17959829
- the interaction between the PTB domain of Mint3 and the acidic peptide signal of Furin regulates the specific localization of Furin in the trans-Golgi network PMID: 18544638
- Mint3 regulates the FIH-1-HIF-1 pathway, which controls ATP production in macrophages PMID: 19726677
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亞細胞定位：Cytoplasm, perinuclear region.
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組織特異性：Expressed in all tissues examined with lower levels in brain and testis.
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數據庫鏈接：
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