ANO6 Antibody, HRP conjugated

說(shuō)明書

中文名稱：

ANO6兔多克隆抗體, HRP偶聯(lián)
貨號(hào)：

CSB-PA679761LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ANO6 Polyclonal antibody
Uniprot No.：

Q4KMQ2
基因名：

ANO6
別名：

2900059G15Rik antibody; AA407480 antibody; Ano6 antibody; ANO6_HUMAN antibody; Anoctamin 6 antibody; Anoctamin-6 antibody; AW554778 antibody; BDPLT7 antibody; F730003B03Rik antibody; MGC104751 antibody; SCTS antibody; TMEM16F antibody; Transmembrane protein 16F antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Anoctamin-6 protein (12-100AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
基因功能參考文獻(xiàn)：
1. ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6. PMID: 28125837
2. TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT signaling pathways. PMID: 27287741
3. Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms PMID: 26108457
4. deficiency in Ano6 resulted in reduced viability with increased bleeding time PMID: 26481309
5. ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys. PMID: 26448322
6. Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets. PMID: 26057829
7. Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. PMID: 25651887
8. using human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID: 25589784
9. Anoo6 induces a chloride ion conductance along with a smaller nonselective cation conductance that is activated either calcium ion dependently (ionomycin) or calcium independently(fas receptor), but not during mitochondrial apoptosis. PMID: 23618909
10. a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population PMID: 23308121
11. TMEM16F is an essential component of a divalent calcium ion-activated Cl- channel with a divalent calcium ion sensitivity that is distinct from that of TMEM16A/B and not related to volume-sensitive outwardly rectifying Cl- channel (VSOR) activity. PMID: 23426967
12. It scrambles phospholipids in cell membrane and its mutation leads to Scott syndrome. (review) PMID: 22256604
13. Study identified 2 novel mutations in the TMEM16F gene in 2 patients with Scott syndrome. PMID: 21511967
14. Wild-type TMEM16F was localized on the plasma membrane and conferred Ca(2+)-dependent scrambling of phospholipids PMID: 21107324
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相關(guān)疾病：

Scott syndrome (SCTS)
亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization according to PubMed:22075693.
蛋白家族：

Anoctamin family
組織特異性：

Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 25240

OMIM: 262890

KEGG: hsa:196527

STRING: 9606.ENSP00000409126

UniGene: Hs.505339

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