-
中文名稱：
AMICA1兔多克隆抗體
-
貨號：
CSB-PA001668GA01HU
-
規格：
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：
JAML
-
別名：
adhesion molecule AMICA antibody; Adhesion molecule interacting with CXADR antigen 1 antibody; adhesion molecule interacts with CXADR antigen 1 antibody; adhesion molecule that interacts with CXADR antigen 1 antibody; AMICA antibody; Amica1 antibody; CREA7-1 antibody; CREA7-4 antibody; Dendritic cell-specific protein CREA7-1 antibody; dendritic-cell specific protein CREA7-1 antibody; dendritic-cell specific protein CREA7-4 antibody; FLJ37080 antibody; Gm638 antibody; JAML1_HUMAN antibody; junctional adhesion molecule antibody; Junctional adhesion molecule-like antibody; Junctional adhesion molecule-like precursor antibody; MGC118814 antibody; MGC118815 antibody; UNQ722/PRO1387 antibody
-
宿主：
Rabbit
-
反應種屬：
Human
-
免疫原：
Human AMICA1
-
免疫原種屬：
Homo sapiens (Human)
-
抗體亞型：
IgG
-
純化方式：
Antigen Affinity purified
-
濃度：
It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
-
產品提供形式：
Liquid
-
應用范圍：
ELISA,WB
-
Protocols：
-
儲存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點詳情
-
功能：
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
-
基因功能參考文獻：
- expressed on leukocytes with a possible role in leukocyte transmigration PMID: 12869515
- Integrin activation is required for the dissociation of JAM-L-VLA-4 complexes and the accumulation of functional JAM-L dimers, which indicates that the leukocyte integrin VLA-4 controls JAM-L function in cis by controlling its dimerization state. PMID: 19064666
-
亞細胞定位：
Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
-
蛋白家族：
Immunoglobulin superfamily
-
組織特異性：
Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).
-
數據庫鏈接：
Most popular with customers
