AMH Antibody

中文名稱：

AMH兔多克隆抗體
貨號：

CSB-PA12639A0Rb
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA12639A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA12639A0Rb at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA12639A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: AMH antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60 kDa
Observed band size: 60 kDa

IHC image of CSB-PA12639A0Rb diluted at 1:1400 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AMH Polyclonal antibody
Uniprot No.：

P03971
基因名：

AMH
別名：

AMH antibody; MIF antibody; Muellerian-inhibiting factor antibody; Anti-Muellerian hormone antibody; AMH antibody; Muellerian-inhibiting substance antibody; MIS antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Muellerian-inhibiting factor protein (26-560AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，AMH Antibody (CSB-PA12639A0Rb)，的標記方式是Non-conjugated。對于AMH Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA12639B0Rb	AMH Antibody, HRP conjugated	ELISA
FITC	CSB-PA12639C0Rb	AMH Antibody, FITC conjugated
Biotin	CSB-PA12639D0Rb	AMH Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:100-1:1500
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
基因功能參考文獻：
1. Women with higher testosterone and AMH had more frequent anovulatory cycles but there were marginal impacts on time to pregnancy or pregnancy loss. PMID: 29428315
2. These findings indicate a pregnancy-associated AMH-decline independent of pre-pregnancy elevated AMH levels. PMID: 30146442
3. serum AMH levels were negatively correlated with age. AMH concentrations approximately 31.1% depended on age and descended by an average of 6.2% per year. Around 25, 35 and 40 years, the decrease of AMH values accelerated. PMID: 29671678
4. AMH is a poor independent predictor of live birth outcome in either fresh or frozen embryo transfer. PMID: 29331235
5. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis or fallopian tube damage, though they are biomarkers for anovulatory fertility disorders. PMID: 29595066
6. serum levels between women with insulin resistance and without insulin resistance in polycystic ovary syndrome were not significantly different PMID: 29605710
7. Data suggest that serum levels of AMH are down-regulated during second half of gestation in (1) women with gestational diabetes, (2) pregnant women with type 2 diabetes, and (3) control pregnant women. A positive association between AMH and testosterone levels was observed in all groups. Also, serum AMH levels are negatively associated with maternal age in the population studied. PMID: 28758808
8. Data confirm that serum levels of AMH decline as function of age (not menstrual cycle) in women ages 20-50; here, results of ELISA assays of serum levels of AMH vary according to kit used. These studies were conducted at a fertility clinic in Poland; serum AMH is proposed as biomarker for ovarian reserve. PMID: 28792788
9. AMH single nucleotide polymorphism is associated with Endometriosis-associated infertility. PMID: 28831646
10. This study demonstrated the existence of an AMH-FOXL2 relationship in hGCs. AMH is capable of increasing both gene and protein expression of FOXL2. Because FOXL2 induces AMH transcription, these ovarian factors could be finely regulated by a positive feedback loop mechanism to preserve the ovarian follicle reserve. PMID: 28660501
11. Data suggest that circulating AMH influences development of human brain; high levels of circulating AMH are unique to developing boys; here, boys age 5-6 years exhibit up-regulation of circulating AMH but are delayed in maturity index (judged by drawings) as compared to girls age 5-6 years. This study was conducted in New Zealand. PMID: 28593614
12. The combination of GDF9 + BMP15 potently stimulates AMH expression in primary cumulus cells. PMID: 28874516
13. serum level elevated in polycystic ovary syndrome PMID: 27899014
14. Surface plasmon resonance analysis showed no significant association between FS288 and AMHC , suggesting that FS288 indirectly regulates AMH signaling. Activin A, a direct target of FS288, did not itself induce reporter activity in P19 cells, but did prevent the FS288-induced increase in AMH signaling. Hence, local concentrations of FS288 and Activin A may influence the response of some cell types to AMH. PMID: 28500669
15. The current study showed no significant difference in AMH level between Sudanese women with preeclampsia and the controls. AMH level was not associated with age, parity, gestational and body mass index. PMID: 28646929
16. In a 46,XY phenotypically female patient bearing testes in inguinal canal, and diagnosed with complete androgen insensitivity syndrome, the dysfunctioning of AR by mutation enhanced AMH expression which ultimately leads to the failure in maturation of Sertoli cells. PMID: 28299491
17. These findings underscore the importance of screening young females with AMH for possible occult primary ovarian insufficiency. PMID: 29176793
18. Women with unexplained infertility did not show evidence of decreased ovarian reserve as measured by AMH and antral follicle count. PMID: 29202959
19. An undetectable AMH level in women aged <40 at the end of chemotherapy for early stage breast cancer gave a good prediction that ovarian function would not return. PMID: 29117576
20. In granulosa cells from women with PCOS, the regulation of AMH and AMHR2 expression is altered in a way that promotes the overexpression of the AMH/AMHR2 system, and could contribute to the follicular arrest observed in these patients. PMID: 28938480
21. genetic variants of AMH or AMHR2 were not found to be associated with a higher risk for polycystic ovaries syndrome. PMID: 27664518
22. Strong positive age-independent relationship between AMH level and the rate of euploid blastocysts I in vitro fertilization/intracytoplasmic sperm injection was found. PMID: 28987789
23. The ratio of inactive proAMH precursor to receptor-competent AMHN,C differs in women with polycystic ovary syndrome relative to unaffected controls indicating that AMH signaling mechanisms may be altered in women with PCOS. PMID: 29079276
24. Study found 24 rare AMH variants in patients with PCOS and control subjects; 18 variants were specific to women with PCOS. Seventeen of 18 (94%) PCOS-specific variants had significantly reduced AMH signaling, whereas none of 6 variants observed in control subjects showed significant defects in signaling. PMID: 28505284
25. In the obese polycystic ovary syndrome group, anti-mullerian hormone was associated with ghrelin levels independent of age, insulin, and total testosterone. There was no association between total ghrelin and anti-mullerian hormone levels in non-obese women with polycystic ovary syndrome, non-obese controls, or obese controls. PMID: 28004236
26. Data suggest that young men and young women initially have similar levels of circulating levels of AMH, but women lose their AMH in parallel with the decrease in their ovarian reserve. Circulating AMH in men is negatively associated with all-cause mortality; men with higher levels of AMH may outlive men with lower levels of AMH. [EDITORIAL] PMID: 27819112
27. In young women with polycystic ovary syndrome, low AMH levels predict a greater risk of metabolic syndrome. PMID: 27842995
28. MIS/AMH inhibits ovarian cancer by deregulating the Wnt signal pathway via the beta-catenin interacting protein (ICAT). MIS/AMH upregulated ICAT in ovarian cancer cell line which caused decreased cell viability, cell cycle arrest and apoptosis. PMID: 28197641
29. The AMH level peaked at or before ovulation in most women, trended down with natural pregnancies, and consistently increased or decreased in women with a viable pregnancy after therapy. Nonviable pregnancies showed erratic AMH patterns. PMID: 27565260
30. Before 35 years of age, women with type 1 diabetes have lower AMH levels than women without diabetes. PMID: 27475411
31. Report variations in antimullerian hormone levels during the menstrual cycle. PMID: 27351446
32. Suggest that activation of AMH by proteolytic enzymes is largely stable throughout the ovarian cycle. However, there is a subtle but robust decrease in the level of proAMH relative to AMHN,C in the acute postovulatory period. PMID: 27362611
33. Age is correlated with AMH, but it accounts for only a portion of the variation seen in reproductive age African American women. PMID: 27114331
34. AMH was inversely correlated with age in both the fertile and infertile populations and there was no significant difference between the fertile and infertile populations in terms of AMH. PMID: 27499425
35. Data suggest that, in adolescents (as with adults) with PCOS (polycystic ovary syndrome), serum levels of 17-hydroxyprogesterone are variable as a characteristic of the disorder; 17-hydroxyprogesterone responsiveness to r-hCG (recombinant human chorionic gonadotropin, a fertility agent) is not correlated to serum levels of AMH (anti-Mullerian hormone). PMID: 27166718
36. Anti-Mullerian hormone (AMH) and inhibin-A (INH-A) levels were found to be significantly higher in the polycystic ovary syndrome (PCOS) group compared to the controls. PMID: 27125339
37. a significant positive correlation between serum asymmetric dimethylarginine and AMH levels in primary dysmenorrhea, is reported. PMID: 27523455
38. Data suggest that the serum AMH level (a biomarker of ovarian reserve) in adolescent girls newly diagnosed with Hashimoto's thyroiditis (HT) is up-regulated compared to age- and BMI-matched control subjects; serum AMH levels are negatively correlated with serum biomarkers of oxidative stress in HT. PMID: 27343736
39. Significantly lower serum AMH concentration was found in the regularly menstruating CKD women on hemodialysis in comparison with the healthy controls. 2. Serum AMH decreased significantly after successful kidney transplantation. PMID: 27553045
40. AMH levels in serum and seminal plasma in healthy men and men with sperm pathology PMID: 27110929
41. Genotyping of the AMH c.146G>T and AMHR2 -482A>G polymorphisms does not provide additional useful information as a predictor of ovarian reserve or ovarian response and treatment outcomes. PMID: 27142041
42. The aim of this study was to investigate the density and distribution of single nucleotide polymorphisms (SNPs) anti-Mullerian hormone (AMH) and AMHRII receptors in cryptorchid patients. PMID: 27162065
43. No evidence of significant associations of Ile49Ser and -482A>G with reproductive outcomes and polycystic ovary syndrome. PMID: 27832628
44. Different phenotypes for polycystic ovary syndrome were identified with each related to different levels of anti-mullerian hormone. PMID: 26718304
45. Data from a longitudinal, observational study suggest that, among women with type 1 diabetes, AMH levels in serum decline in manner similar to that previously reported in women without diabetes; thus, it is possible that AMH may be used to risk-stratify women with type 1 diabetes at risk for diminished ovarian reserve and poor reproductive outcomes in a similar manner as used in healthy women. PMID: 26798983
46. Ile(49)Ser genotype not associated with estradiol levels, ovarian parameters, menstrual cycle length, or pregnancy outcomes in healthy Singapore women PMID: 26633196
47. High serum Anti-Mullerian Hormone levels are associated with Polycystic Ovary Syndrome. PMID: 26761944
48. Women with systemic lupus erythematosus demonstrated similar AMH levels as healthy controls, suggesting preserved ovarian reserve in this population. PMID: 26223296
49. These findings contribute in clarifying the relationship between hormones regulating the early phase of steroidogenesis confirming that AMH is playing a suppressive role on CYP19A1 expression stimulated by gonadotropin in hGCs. Furthermore, a similar inhibitory effect for AMH was observed on P450scc gene expression when activated by gonadotropin treatment. PMID: 26631403
50. The AMH and AMHRII gene polymorphisms were not found a significant difference in non-IR-PCOS and normal groups. To IR-PCOS women, genotypes of AMH were closely related to the serum levels of LH (P = 0.000), testosterone (P = 0.000) and HOMA-IR (P = 0.038), while in the non-IR-PCOS and normal groups, no relationship was found PMID: 26732661
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相關疾病：

Persistent Muellerian duct syndrome 1 (PMDS1)
亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family
數據庫鏈接：

HGNC: 464

OMIM: 261550

KEGG: hsa:268

STRING: 9606.ENSP00000221496

UniGene: Hs.112432

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