AMBP Antibody, FITC conjugated

說明書

中文名稱：

AMBP兔多克隆抗體, FITC偶聯
貨號：

CSB-PA10009C0Rb
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AMBP Polyclonal antibody
Uniprot No.：

P02760
基因名：

AMBP
別名：

A1M antibody; Alpha 1 microglobulin/bikunin precursor antibody; Alpha 1 microglycoprotein antibody; Alpha-1 microglycoprotein antibody; Alpha-1-microglobulin antibody; AMBP antibody; AMBP_HUMAN antibody; Bikunin antibody; Complex-forming glycoprotein heterogeneous in charge antibody; EDC1 antibody; Growth inhibiting protein 19 antibody; HCP antibody; HI-30 antibody; HI30 antibody; IATIL antibody; ITI antibody; ITI-LC antibody; ITIL antibody; Microglobulin (alpha 1) antibody; Protein AMBP antibody; Protein HC antibody; Trypstatin antibody; Uristatin antibody; Uronic-acid-rich protein antibody; UTI antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein AMBP protein (20-203AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.; Trypstatin is a trypsin inhibitor.
基因功能參考文獻：
1. There were significantly higher serum concentrations of fetal hemoglobin and alpha1-microglobulin and significantly lower first trimester serum concentrations of hemopexin in patients who later developed preeclampsia. PMID: 27155336
2. Prophylactic UTI maintains the endothelial barrier function, increases VE-cadherin expression, and inhibits the phosphorylation of VE-cadherin at Tyr658 under inflammatory conditions PMID: 26681130
3. Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. PMID: 26728454
4. Data indicate that two heme groups can be bound simultaneously at separate sites in the antioxidant alpha1-microglobulin. PMID: 26497278
5. results indicate a reduced UTI level in CSF of MS and NMO patients. The levels were associated with the severity of the two demyelinating diseases during relapse PMID: 25555815
6. Proximal tubular dysfunction, indicated by urine alpha1-microglobulin, was independently associated with kidney function decline in HIV-infected and uninfected women and mortality risk among HIV-infected women. PMID: 25370597
7. placental alpha microglobulin-1 is a sensitive and specific test to assess rupture of membranes in patients with an equivocal diagnosis based on simple tests PMID: 24698819
8. Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan. PMID: 25561734
9. Decreased bikunin mRNA level in renal cells might be associated with poor prognosis of renal carcinoma. PMID: 24980765
10. The antioxidative protection of cells and collagen by A1M is totally dependent on its C34 amino acid residue. PMID: 23642167
11. Label-free quantitative comparison of DN urinary exosomes vs control group and SRM further validation, resulted in the discovery of a panel of three proteins (AMBP, MLL3 and VDAC1) which changes in DN. PMID: 24211404
12. The high level of serum AMBP could predict the poor response of the AGC patients. PMID: 24135868
13. In pre-term pregnant women with intact membranes, placental alpha-microglobulin-1 in cervicovaginal fluid test rates are more positive in cases of uterine contraction. PMID: 23919851
14. our findings suggest that urine bikunin level, as well as proteinuria, could represent a useful parameter for monitoring renal function in those patients that do not present any symptoms of renal insufficiency. PMID: 23841057
15. Determined is the first structure of human alpha-1-microglobulin with heavy electron density of the chromophore. PMID: 24012674
16. Sulfation of the bikunin chondroitin sulfate chain determines heavy chain.hyaluronan complex formation PMID: 23801333
17. High urine alpha-1-microglobulin is associated with interstitial fibrosis and tubular atrophy plus inflammation. PMID: 23414180
18. High urine alpha-1-microglobulin is associated with ischemic acute tubular necrosis than other causes of acute kidney injury. PMID: 23324582
19. Report prognostic value of urinary alpha 1-macroglobulin in idiopathic membranous nephropathy. PMID: 22595828
20. crystal of alpha1-microglobulin belonged to space group P4(3), with unit-cell parameters a = b = 36.45, c = 112.68 A PMID: 22684072
21. The results suggest that A1M may have a physiological role in protection of skin cells and matrix against oxidative damage following bleeding. PMID: 22096585
22. urinary marker for the differential diagnosis of Balkan endemic nephropathy PMID: 21332340
23. These findings suggest that there was no significant association in genotype distribution of Init-2 polymorphism of the AMBP gene between patients with kidney stones and healthy controls. PMID: 20602574
24. the cell-protective effects of alpha(1)-microglobulin during alpha-particle irradiation PMID: 20954860
25. The promoter of AMBP gene had polymorphisms at positions -218 and -189 nt giving three different genotypes with no association between these observed genotypes and kidney stone-forming phenotypes. PMID: 20602574
26. increased protein levels in preeclamptic women PMID: 19879940
27. significant relationship was established between the low level and absence of bikunin, and pro-u-PA in urine samples from patients with bladder tumors; identified bikunin loss in urine as a potential bladder carcinoma marker PMID: 19914646
28. Transfection into H460M Human large cell lung carcinoma line decreased tumor growth and metastasis in nude mice PMID: 11807786
29. Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties. PMID: 11877257
30. bikunin has a role in downregulating PI3 kinase and suppressing tumor invasiveness and metastasis in ovaran cancer cells PMID: 14597629
31. Data show that alpha(1) -microglobulin/bikunin precursor specifically interacts with the ORF3 protein of hepatitis E virus and has a direct role in enhancing alpha(1)microglobulin export from the hepatocyte. PMID: 15037615
32. alpha-1-microglobulin is covalently bound to kynurenine-derived chromophores PMID: 15452109
33. Bikunin neither decreased expression of TGF-beta receptors (TbetaRI and TbetaRII) in cancer cells nor altered the specific binding of 125I TGF-beta1 to the cells. PMID: 15498571
34. The TSG-6 and inter-alpha-inhibitor interaction promotes a transesterification cleaving the protein-glycosaminoglycan-protein (PGP) cross-link. PMID: 15653696
35. the second processed protein from AMBP, bikunin, strongly interacted with the full-length hepatitis E virus ORF3 protein PMID: 16140784
36. the ORF3 protein exploits the endosomal sorting machinery to enhance the secretion of an immunosuppressant molecule (alpha1 microglobulin) from cultured hepatocytes PMID: 16407257
37. Identification of the protein bikunin as an endogenous, competitive inhibitor of a dynorphin-converting enzyme in human cerebrospinal fluid. PMID: 17087727
38. Free uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma. PMID: 17115277
39. Bikunin was found to localize on the cell membrane, while tryptase was in the secretary granules of the mast cells from psoriatic lesions. PMID: 17146627
40. alpha(1)-microglobulin participates in the defense against oxidation by hemoglobin, heme, and reactive oxygen species PMID: 17320766
41. small angle X-ray scanning study of the monomer and dimer forms of alpha1-microglobulin; monomer is characterised by a radius of gyration R(G)= 2.20 nm and D(max)=6.3 nm and the dimer by R(G)=2.99 nm and D(max)=9.5 nm PMID: 17584166
42. The ability of alpha-1-microglobulin to restore the initial conformation characteristic for the native protein and the internal dynamics after the unfolding of the globule by 10 M urea and 6 M guanidine hydrochloride has been ascertained. PMID: 17633530
43. AMBP has radical scavenging activity. PMID: 17766242
44. urinary trypsin inhibitor is insufficiently produced for neutrophil elastase release after cardiac arrest PMID: 17998887
45. in multiple myeloma patients without renal failure, elevated Alpha-1-microglobulin excretion might be an early marker of renal tubular involvement PMID: 18046670
46. In the present study, structural motifs regulating bikunin's anti-inflammatory function are delineated. Binding of bikunin to neutrophils is critically important for its anti-inflammatory capacity. PMID: 18226914
47. The transfer of heavy chains from bikunin proteins to hyaluronan requires both TSG-6 and HC2. PMID: 18448433
48. Overexpression of bikunin reduced the gene expression of matriptase, which attenuated in vitro cell invasion in prostate cancer. PMID: 18649735
49. Overexpression of Urinary trypsin inhibitor is associated with recurrence in hepatocellular carcinoma. PMID: 19636634
顯示更多

收起更多
亞細胞定位：

Secreted.
蛋白家族：

Calycin superfamily, Lipocalin family
組織特異性：

Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha-trypsin inhibitor is present in plasma and urine.
數據庫鏈接：

HGNC: 453

OMIM: 176870

KEGG: hsa:259

STRING: 9606.ENSP00000265132

UniGene: Hs.436911

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human