ALX4 Antibody

說明書

中文名稱：

ALX4兔多克隆抗體
貨號：

CSB-PA992612
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA992612(ALX4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA992612(ALX4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9H161
基因名：

ALX4
別名：

Alx4 antibody; ALX4_HUMAN antibody; Aristaless like homeobox 4 antibody; CRS5 antibody; FND2 antibody; FPP antibody; homeobox protein aristaless like 4 antibody; Homeobox protein aristaless-like 4 antibody; homeodomain transcription factor ALX4 antibody; KIAA1788 antibody; PFM1 antibody; PFM2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human ALX4
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
基因功能參考文獻：
1. We reveal for the first time that ALX4 acts as a novel functional tumor suppressor inactivated by DNA methylation and is an independent prognostic factor in breast cancer PMID: 29183346
2. overexpression of ALX4 inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT) in HCC cells. ALX4 had an inhibitory effect on the sonic hedgehog (Shh) signaling pathway. PMID: 28081728
3. mother of Case 2 also had a mutation in the ALX4 gene, but no enlarged parietal foramina PMID: 27349084
4. Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells. PMID: 25944620
5. High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. PMID: 24941917
6. We suggest that all ALX4 heterozygote carriers be examined in detail for possible changes in nasal configuration, to establish a detailed genotype-phenotype correlation, leading the way to more comprehensive genetic counseling. PMID: 24764194
7. Epigenetic silencing of Aristaless-like homeobox-4 is associated with lung cancer. PMID: 24037716
8. study describes 2 related individuals with a heterozygous mutation in ALX4 presenting a distinct phenotype of frontonasal dysplasia; suggest that the loss of the ALX4 OAR domain with the maintenance of the homeodomain impairs the function of the normal allele in a dominant-negative effect PMID: 23401352
9. ALX4 variants may have an impact on the genetic etiology of nonsyndromic craniosynostosis. PMID: 22829454
10. Exclusion of mutations in ALX4 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies PMID: 22496059
11. Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation. PMID: 20625746
12. Data show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. PMID: 20140221
13. data show a distinct pattern of expression of ALX4 in the human breast relative to the murine mammary gland, and the loss of ALX4 in tumours and the surrounding untransformed stroma is a basic characteristic of ductal carcinoma. PMID: 19783719
14. ALX4 plays a critical role in craniofacial and epidermal development. PMID: 19692347
15. One subject with parietal foramina whose deletion does not include ALX4 indicates that ALX4 in this subject may be rendered functionally haploinsufficient by a position effect. PMID: 15852040
16. The ALX4 mutation p.R218Q tends to result in persistent cranium bifidum and is associated with anatomical abnormalities of the posterior fossa. PMID: 16319823
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相關疾病：

Parietal foramina 2 (PFM2); Frontonasal dysplasia 2 (FND2); Potocki-Shaffer syndrome (POSHS); Craniosynostosis 5 (CRS5)
亞細胞定位：

Nucleus.
蛋白家族：

Paired homeobox family
組織特異性：

Expression is likely to be restricted to bone. Found in parietal bone.
數據庫鏈接：

HGNC: 450

OMIM: 601224

KEGG: hsa:60529

STRING: 9606.ENSP00000332744

UniGene: Hs.436055

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