AICDA Antibody
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中文名稱：AICDA兔多克隆抗體
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貨號：CSB-PA006133
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規格：￥1090
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圖片：
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Western Blot analysis of Hela HepG2 cells using AID Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Activation induced cytidine deaminase antibody; Activation induced deaminase antibody; Activation-induced cytidine deaminase antibody; AICDA antibody; AICDA_HUMAN antibody; AID antibody; ARP 2 antibody; ARP2 antibody; CDA 2 antibody; CDA2 antibody; Cytidine aminohydrolase antibody; HIGM2 antibody; Integrated into Burkitt's lymphoma cell line Ramos antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human AID.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
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基因功能參考文獻：
- this study reports the clinical and AID genetic features of six Iranian hyper IgM syndrome patients PMID: 30081731
- induction of AID expression would result in chromosomal translocations in the process of differentiation from B cell derived induced pluripotent stem cells. PMID: 28490810
- The distribution of AID and A3s in the epithelial cells as well as germinal centres. PMID: 29343743
- patients with AS expressed significantly higher levels of sv2 than HC. TNFi treatment restored the gene expression of the AID variants (FL, sv1, and sv2) in patients with AS. Therefore pre-existing TNFalpha-induced AID expression in B cells may play a role in the pathogenesis of AS. PMID: 28959900
- we reported high AID, low miR-181b and high miR-155 expression in de novo adult B-ALL patients. Univariate high AID or low miR-181b expression was an unfavorable prognostic factor. High AID with low miR-181b or with low miR-155 expression is better in predicting unfavorable OS than univariate factor. High AID with low miR-181b and low miR-155 expression confers worst prognosis. PMID: 28140712
- AID expression was increased in chronic lymphocytic leukemia patients with del17p or del11q who have poor prognosis. PMID: 28388279
- Results indicate activation-induced cytidine deaminase (AICDA) as a driver of epigenetic heterogeneity in B-cell lymphomas with potential significance for other tumors with aberrant expression of cytidine deaminases. PMID: 29335468
- The binding and catalytic behavior of purified AID was tested on DNA/RNA hybrid substrates bearing either random sequences or GC-rich sequences simulating Ig S regions. AID exhibited a higher affinity for binding DNA/RNA hybrid substrates made of S region sequences, than any other DNA substrates. In the absence of any other cellular processes or factors, AID itself favors binding and mutating S-region DNA/RNA hybrids. PMID: 29161581
- Expression of human AID or increased oxidative stress induces DNA breaks within human chromosomal translocation fragile zones. PMID: 29220655
- Data implicate intrinsic preference of AID for structured substrates and uncover the importance of G4 recognition and oligomerization of AID in class switch recombination. PMID: 28757211
- the His130Pro mutation allows the enzyme to retain its mutagenic activity and would prevent the interaction of AID with specific cofactors required for class switch recombination but not for somatic hypermutation. Thus, there would be no contradiction between maintaining the catalytic and mutagenic activity of AID and the presence of function defects at the genomic level. PMID: 27716525
- The authors found that the viral epsilon RNA and C-terminus of AID are required for AID-mediated hepatitis B virus RNA reduction. PMID: 28779685
- silencing of AID in human bone marrow cells skews differentiation toward myelomonocytic lineage. However, in contrast to Tet2 loss, Aid loss does not contribute to enhanced HSC self-renewal or cooperate with Flt3-ITD to induce myeloid transformation. Genome-wide transcription and differential methylation analysis uncover the critical role of Aid as a key epigenetic regulator PMID: 28077417
- AID protein is expressed in a large proportion of Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia cases at levels detectable by immunohistochemistry. PMID: 26980048
- These data, showing the direct targeting and induction of functional AID by EBNA3C, suggest a novel role for EBV in the etiology of B cell cancers, including endemic Burkitt lymphoma PMID: 27217538
- These findings indicated that TNF-alpha-induced AID expression is involved with class switch recombination in cancer. PMID: 25849121
- Finnish founder allele causing HIGM2 identified. PMID: 27142677
- Structural analysis of AID protein required in immunoglobulin diversification has been reported. PMID: 27258794
- this study reports a case of growth hormone deficiency with an autosomal recessive Hyper-immunoglobulin M syndrome by phenotype and genotype, with a novel mutation in AICDA that has not been reported formerly PMID: 27789066
- We also report that AID activity results in epigenetic, genetic and genomic damage in fallopian tube epithelial cells PMID: 26936395
- AICDA/APOBEC family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. (Review) PMID: 26398702
- DNA methylation dynamics of germinal center B cells are mediated by AID. PMID: 26365193
- Mutations in activation-induced cytidine deaminase is associated with indolent chronic lymphocytic leukaemia. PMID: 26638776
- Data suggest novel mechanism in innate immunity allows cytokine TGF-beta to restrict viral circular DNA in hepatocyte nuclei via innate immunity; AID deaminates circular DNA of hepatitis B virus leading to DNA degradation; mechanism depends on UNG. PMID: 26867650
- The high levels of memory and activated B cells and follicular helper T cells were positively associated with the progression of immunoglobulin A nephropathy. This may be mediated by the overexpression of AID, which is potentially regulated by IL21. PMID: 26166388
- identify AID derivatives that accelerate somatic hypermutation with minimal impact on viability, which will be useful tools for engineering genes and proteins by iterative mutagenesis and selection PMID: 26355458
- High expression of activation-induced cytidine deaminase is associated with diffuse large B cell lymphoma. PMID: 26077666
- AID mutations leading to AID deficiency are the most frequent underlying molecular basis of hyper IgM syndrome in consanguineous Tunisian patients. PMID: 26545377
- Studies indicate that gene conversion mediated by activation-induced cytidine deaminase (AID) has been found to contribute to generation of the primary antibody repertoire. PMID: 26537386
- aberrant expression of AID may reflect continuous B cell activation and sustained survival signals in HCV-related CV patients. PMID: 26219420
- Surges in ERK activity induced by extracellular cues enhance Arp2/3-mediated actin polymerization to generate protrusion power phases sufficient to promote sustained cell motility. PMID: 25990957
- Data show that microRNAs miR-155 and miR-16 downregulate activation-induced cytidine deaminase (AID) and transcription factor E47 in B Cells through binding of the 3'-untranslated regions. PMID: 26223652
- Data indicate that both the amount and intensity of the activation-induced cytidine deaminase (AID) protein expression increased with the progression from precancerous to cancerous lesions in pancreatic ductal adenocarcinoma (PDAC) tissues. PMID: 26113087
- B cells hijack to supply ssDNA substrates for AID to mutate at immunoglobulin V regions during somatic hypermutation. PMID: 24923561
- HSP90 inhibitors indirectly target AID in vivo PMID: 25912253
- findings suggest that AID has a role in the development of oral epithelial dysplasia and promotes progression of oral cancer PMID: 24351917
- hnRNP K and hnRNP L may serve as A1CF-like cofactors in AID-mediated class switch recombination and somatic hypermutation PMID: 25902538
- Activation-induced cytidine deaminase (AID)-induced mutagenic U:G mismatches in DNA may be a fundamental and common cause of mutations in B-cell malignancies. PMID: 25486549
- In yeast, AID and the catalytic domain of APOBEC3G preferentially mutate transcriptionally active genes within narrow regions, 110 base pairs in width, fixed at RNA polymerase initiation sites. PMID: 25237741
- There was no significant association between the previously reported genetic variant of AICDA gene and the development of Common variable immunodeficiency or selective IgA deficiency PMID: 23731676
- demonstrates that intensity of malaria transmission correlates with AID expression levels in the presence of Epstein-Barr virus PMID: 25099163
- Study reports that the majority of detectable AID off-target activity in a variety of mouse and human lymphoid or nonlymphoid cell types occurs within focal regions of overlapping sense/antisense transcription within intragenic super enhancers. PMID: 25483776
- AID activity and its relationship to chromosome folding and the B cell regulome was studied; find that AID-mediated lesions occur predominantly within B cell super-enhancers and regulatory clusters; further show that the structural and transcriptional features of these domains help explain AID tumorigenic activity in the B cell compartment of mice and humans. PMID: 25483777
- data demonstrate that AID is active in CLL in vivo and thus, AID likely contributes to clonal evolution of CLL. PMID: 25179679
- analysis of a possible association between AID expression and BRAF mutation in melanoma PMID: 24684646
- Results show that both AID mRNA levels and DNA-cytosine deamination activities follow the same general pattern of increase and decline after stimulation in the two genetic backgrounds. PMID: 25154417
- DNA repair pathways which are in vitro activated by AID-induced lesions are reminiscent of those found during AID-induced in vivo immunoglobulin diversification. PMID: 24349193
- Results show that activation induced cytidine deaminase (AID) expression may be associated with deletions in patients with chronic lymphocytic leukemia (CLL). PMID: 23662991
- AID lacking the C terminus is impaired in its ability to recruit nonhomologous end joining repair factors, resulting in accumulation of double-strand breaks that undergo aberrant resection. PMID: 24973444
- findings reveal additional functions for AID in innate immune defense against KSHV with implications for a broader involvement in innate immunity to other pathogens. PMID: 24244169
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相關疾病：Immunodeficiency with hyper-IgM 2 (HIGM2)
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：Cytidine and deoxycytidylate deaminase family
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組織特異性：Strongly expressed in lymph nodes and tonsils.
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數據庫鏈接：
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