AGAP2 Antibody
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中文名稱：AGAP2兔多克隆抗體
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貨號：CSB-PA001427GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：AGAP-2 antibody; Agap2 antibody; Agap2 ArfGAP with GTPase domain; ankyrin repeat and PH domain 2 antibody; AGAP2_HUMAN antibody; ANK repeat and PH domains 2 antibody; Arf GAP with GTP binding protein like antibody; Arf GAP with GTP-binding protein-like; ANK repeat and PH domains 2 antibody; Arf GAP with GTP-binding protein-like; ankyrin repeat and pleckstrin homology domains 2 antibody; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 2 antibody; ArfGAP with GTPase domain; ankyrin repeat and PH domain 2 antibody; Centaurin gamma 1 antibody; centaurin gamma1 antibody; Centaurin-gamma-1 antibody; Centg1 antibody; cnt g1 antibody; Cnt-g1 antibody; Cnt2 antibody; FLJ16430 antibody; GGAP2 antibody; GTP binding and GTPase activating protein 2 antibody; GTP-binding and GTPase activating protein 2 antibody; GTP-binding and GTPase-activating protein 2 antibody; KIAA0167 antibody; mKIAA0167 antibody; Nuclear GTPase PIKE antibody; Phosphatidylinositol 3-kinase enhancer antibody; Phosphoinositide 3 kinase enhancer antibody; PI3K ENHANCER antibody; PIKE antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human AGAP2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
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基因功能參考文獻：
- A pleckstrin homology domain in PIKE-L directly binds alpha-synuclein and antagonizes its aggregation. Accordingly, PIKE-L overexpression decreases dopaminergic cell death elicited by MPP(+), whereas PIKE-L knockdown elevates alpha-synuclein oligomerization and cell death. PMID: 28096359
- these findings support that PIKE amplification or overexpression coordinately acts with CDK4 to drive glioblastoma tumorigenesis. PMID: 28368413
- Studies showed that overexpression or mutation of PIKE has been observed in a variety of tumors, promoting cancer cell growth, transformation and invasion through AKT signaling or other signaling pathways, such as focal adhesion kinase. [review] PMID: 26977005
- Mutation of Fyn phosphorylation sites on PIKE-A, depletion of Fyn, or pharmacological inhibition of Fyn blunts the association between PIKE-A and AMPK, resulting in loss of its inhibitory effect on AMPK. PMID: 26001218
- expression of PLC-gamma1 and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma. PMID: 26464646
- PIKE reduction rescued PI3K-dependent and -independent neuronal defects in fragile X syndrome. PMID: 25921541
- In this review the CENTG1 gene is amplified in a variety of human cancers which lead to the enhancement of tumor invasion. PMID: 23770988
- AGAP2 plays a role in the signalling and recycling of beta2-adrenergic receptors. PMID: 23527545
- Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). PMID: 23438599
- PIKE is highly expressed in human squamous cell carcinoma and has a critical role in EGF-induced squamous cell carcinoma proliferation. PMID: 22349826
- The presence of heterogeneous missense mutations of GGAP2 in prostate cancer was associated with aggressive clinical behavior. PMID: 22389719
- PIKE is a critical factor in controlling synaptic AMPA receptor insertion. PMID: 21847098
- Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. [PIKE-A] PMID: 21460185
- regulates retrograde protein transport between early endosomes and the Golgi complex PMID: 20551179
- This study have identified, cloned and characterized PIKE-L, which localizes to both the cytoplasm and the nucleus, activates mGlur1 enhances formation of an mGluRI-Homer-PIKE-L complex, then activates PI3 kinase activity and prevents neuronal apoptosis. PMID: 14528310
- a physiologic regulator of Akt and an oncogenic effector of cell invasion PMID: 14761976
- PIKE binds PI 3-kinase & stimulates its lipid kinase activity. There are 3 isoforms which function throught the cell and meadiate processes from invasiveness to apoptosis. Review. PMID: 15951849
- The AGAP2 colocalized with AP-1, transferrin receptor and Rab4 on endosomes. Overexpression of AGAP2 changed the intracellular distribution of AP-1 and promoted Rab4-dependent fast recycling of transferrin. PMID: 16079295
- an important role of PIKE gene aberrations in the molecular pathogenesis of primary glioblastomas PMID: 16150119
- Fyn is essential for phosphorylating PIKE-A and protects it from apoptotic cleavage. PMID: 16841086
- The results of this study indicate that centaurins could be more accurately classified as NTPases and point to alternative mechanisms of cell signalling control. PMID: 17037982
- Myxoma virus (MV) M-T5 host range protein is functionally interchangeable with the host PIKE-A protein and that the activation of host Akt by either M-T5 or PIKE-A is critical for the permissiveness of cancer cells for MV. PMID: 17151107
- PIKE-A acts as a proto-oncogene, promoting cell transformation through Akt activation. PMID: 17297440
- Ectopic expression of AGAP2 causes both BRAG2 and the coiled bodies' marker coilin to accumulate in nucleoli. PMID: 17461797
- The cytoplasmic-nuclear shuttling of PIKE is dynamically regulated by the balancing actions of the lipid-binding property of both the split PH domain and the nuclear targeting function of its nuclear localization sequence. PMID: 18371979
- In normal mice. PIKE-L strongly binds SET and prevents its degradation by AEP, leading to resistance of neuronal cell death. PMID: 18374643
- PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system PMID: 18469807
- Cdk5 phosphorylates PIKE-A and stimulates its GTPase activity, which activates nuclear Akt and promotes glioblastoma cell migration and invasion. PMID: 18487454
- Increased GGAP2 expression, which is present in three quarters of human prostate cancers, can activate two critical pathways that have been linked to prostate cancer initiation and progression. PMID: 19176382
- AGAP2 regulates the FAK activity and the focal adhesion disassembly during cell migration. PMID: 19318351
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亞細胞定位：[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm.
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蛋白家族：Centaurin gamma-like family
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組織特異性：Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.
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數據庫鏈接：
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