ADI1 Antibody
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中文名稱：ADI1兔多克隆抗體
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貨號：CSB-PA781963
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規格：￥1090
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圖片：
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Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:200
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其他：
產品詳情
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Uniprot No.：
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基因名：ADI1
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別名：1 2 dihydroxy 3 keto 5 methylthiopentene dioxygenase antibody; 1 antibody; 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase antibody; Aci reductone dioxygenase antibody; Acireductone dioxygenase (Fe(2+) requiring) antibody; Acireductone dioxygenase (Ni(2+) requiring) antibody; Acireductone dioxygenase (Ni(2+)-requiring) antibody; Acireductone dioxygenase 1 antibody; ADI 1 antibody; Adi1 antibody; ADI1 antibody antibody; APL1 antibody; ARD antibody; EC 1.13. antibody; Fe ARD antibody; FLJ10913 antibody; HMFT1638 antibody; Membrane type 1 matrix metalloproteinase cytoplasmic tail binding protein 1 antibody; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1 antibody; MT1 MMP cytoplasmic tail binding protein 1 antibody; MTCBP 1 antibody; MTCBP-1 antibody; MTCBP1 antibody; MTND_HUMAN antibody; Ni-ARD antibody; SIPL antibody; Submergence induced protein 2 antibody; Submergence induced protein 2 homolog antibody; Submergence induced protein like factor antibody; Submergence-induced protein 2 homolog antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide from Human protein at AA range: 71-120
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC,ELISA
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推薦稀釋比：
Application Recommended Dilution IHC IHC-p:1:50-300 ELISA 1:10000-20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
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基因功能參考文獻：
- High ADI1 expression is associated with malignant glioma. PMID: 30066900
- The thermal stability of the HsARD isozymes is a function of the metal ion identity, with Ni2+-bound HsARD being the most stable followed by Co2+ and Fe2+, and Mn2+-bound HsARD being the least stable. PMID: 28062648
- In summary, clinical and cell-based experiments suggested that physical interaction between MT1-MMP and ADI1 led to suppression of hepatitis C virus infection. This inhibitory effect could be reversed by ADI1 overexpression. PMID: 26537061
- Data elucidate a new role for MTCBP-1 regulating the intracellular function of MT1-MMP-mediated autophagy. Their inverse expression correlation with brain tumor grades could also contribute to the decreased autophagic index observed in high-grade tumors. PMID: 25640948
- MTCBP-1 is a new member of the Cupin superfamily with a role as an invasion suppressor down-regulated in tumors PMID: 14718544
- nucleo-cytoplasmic transport of hADI1 is regulated by a non-canonical nuclear export signal (NES) located in the N-terminal region of hADI1. PMID: 17212658
- ADI1 may check prostate cancer progression through apoptosis by an activity that does not require metal binding. PMID: 17786183
- 293-ADI1-CD81 cells are permissive for serum-derived HCV infection. PMID: 19626614
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亞細胞定位：Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
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蛋白家族：Acireductone dioxygenase (ARD) family
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組織特異性：Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.
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數據庫鏈接：
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