ADAMTS4 Antibody
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中文名稱：ADAMTS4兔多克隆抗體
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貨號：CSB-PA001311LA01HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA001311LA01HU at dilution of 1:100 -
Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: ADAMTS4 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 91 kDa
Observed band size: 91 kDa -
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001311LA01HU at dilution of 1:100 -
IHC image of CSB-PA001311LA01HU diluted at 1:250 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) ADAMTS4 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4 antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody; ADAM metallopeptidase with thrombospondin type 1 motif 4 antibody; ADAM TS 4 antibody; ADAM TS4 antibody; ADAM-TS 4 antibody; ADAM-TS4 antibody; ADAMTS 2 antibody; ADAMTS 4 antibody; ADAMTS-4 antibody; ADAMTS2 antibody; ADAMTS4 antibody; ADAMTS4 protein antibody; ADMP 1 antibody; ADMP-1 antibody; ADMP1 antibody; Aggrecanase 1 antibody; Aggrecanase-1 antibody; Aggrecanase1 antibody; ATS4_HUMAN antibody; KIAA0688 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human, Mouse
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免疫原：Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 protein (213-319AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁面中的產(chǎn)品，ADAMTS4 Antibody (CSB-PA001311LA01HU)，的標(biāo)記方式是Non-conjugated。對于ADAMTS4 Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:50-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
引用文獻(xiàn)
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
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基因功能參考文獻(xiàn)：
- ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. PMID: 29135310
- ADAMTS4 was associated macrophages infiltration and polarization in the tumor microenvironment of CRC and ADAMTS4 knockdown had no inhibitory implications on cell proliferation and invasion in vitro, but significantly attenuated tumor growth in vivo. PMID: 29694979
- ADAMTS4 expression was upregulated during carotid atherosclerotic plaque development. Serum levels of ADAMTS4 were associated with increased plaque vulnerability in both symptomatic and asymptomatic patients with carotid artery stenosis. PMID: 29153440
- methylation status of the ADAMTS4 gene is altered in patellar tendinopathy PMID: 28888475
- HipHop-based pharmacophore modeling and virtual screening of the Maybridge database to identify novel ADAMTS-4 inhibitors. These novel lead compounds act as potent and specific inhibitors for the ADAMTS-4 enzyme and could have therapeutic potential in the treatment of OA. PMID: 27401455
- ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients. PMID: 28829887
- Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 is a better substrate for ADAMTS-5 than it is for ADAMTS-4. Fibulin-2 degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells. PMID: 28099917
- ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas. PMID: 28323982
- The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration. PMID: 26495885
- Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes PMID: 28081267
- Results show that ADAMTS4 mRNA is the target of mir-1268a and its expression might be modified by MIR-1268a rs28599926 polymorphism in hepatocellular carcinoma. PMID: 26152337
- we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. ADAMTS4 and ADAMTS5 genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population. PMID: 27706574
- ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
- ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in preterm premature rupture of membranes . PMID: 27182768
- in degenerative intervertebral discs, IL1b upregulates NFkB, MMP13 and ADAMTS4 PMID: 25433723
- progesterone acts via the progesterone receptor to modulate ADAMTS 1 and 4 levels in ovarian cancer cell lines. PMID: 26916548
- ADAMTS4 may be responsible for the pathogenesis of atherosclerosis. ADAMTS4 serum levels were also higher in diabetic cases. There is an association between ADAMTS4 and TGFb1 serum levels in the progression of atherosclerosis in coronary artery disease. PMID: 25592103
- Evaluate ADAMTS-4 and ADAMTS-5 immunohistochemical expression in human TMJ discs from patients affected by internal derangement. PMID: 25477257
- These data demonstrate that the antibody is specific to ADAMTS4 and ADAMTS5 and inhibits their aggrecanase activity at molecular and cellular levels. PMID: 26612259
- ADAMTS4 is largely associated with synapses, and is the main brevican-processing protease. PMID: 25225099
- ADAMTS-4 is a potential biomarker and an early diagnostic indicator of knee osteoarthritis. PMID: 25501175
- A positive feedback loop involving sSema4D/IL-6 and TNFalpha/ADAMTS-4 may contribute to the pathogenesis of rheumatoid arthritis. PMID: 25707877
- CCN1 suppresses ADAMTS-4 activity and that CCN1 overexpression is directly correlated with chondrocyte cloning in osteoarthritis cartilage. The TGFbeta/CCN1 axis plays a role in chondrocyte cluster formation through inhibition of ADAMTS-4. PMID: 25709087
- Our results indicate that miR-125b plays an important role in regulating the expression of ADAMTS-4 in human chondrocytes PMID: 23406982
- We conclude that the upregulation of TNF-alpha and ADAMTS-5, but not ADAMTS-4, may play an important role in degenerative cartilage endplate-induced low back pain. PMID: 24732836
- The restricted expression of ADAMTS-4 and ADAMTS-5 and their increased expression in gestational trophoblastic diseases suggest that these 2 ADAMTS subtypes are associated with human placentation and the development of gestational trophoblastic diseases. PMID: 24786121
- This study highlights that the affinity between a ligand and LRP1 dictates the rate of internalization and suggests that LRP1 is a major traffic controller of the two aggrecanases, especially under inflammatory conditions, where the protein levels of ADAMTS-4 increase, but those of ADAMTS-5 do not. PMID: 24474687
- This is the first evidence of crosstalk between TNF-alpha and ADAMTS-4 in relation to osteoarthritis cartilage degradation. PMID: 24126638
- We have demonstrated that the expression of ADAMTS-1, -4 and -5 is induced during the differentiation of monocytes into macrophages. PMID: 23859810
- ADAMTS-4 and its substrate biglycan are involved in tubulogenesis by endothelial cells PMID: 24051360
- ADAMTS-4_v1 is expressed as a protein in vivo in human osteoarthritis synovium, functions as an aggrecanase, and cleaves other proteoglycan substrates. PMID: 23897278
- Cartilage affected by varying degrees of osteoarthritis stained strongly for active ADAMTS-4 where surface fibrillation and clustered chondrocytes were observed. PMID: 23295731
- The purpose of the present study was to investigate the precise molecular mechanisms of high molecular weight hyaluronic acid on ADAMTS4 expression induced by IL- 1b in vitro. PMID: 23438438
- Sp1 transcription factor partly mediates IL-1 induction of ADAMTS-4. PMID: 22065068
- AMTS4 has roles in melanoma growth and angiogenesis PMID: 23319426
- Citrullinated fibronectin is less effective in inhibiting the proteolytic activity of ADAMTS4 and may contribute to the destruction of joint cartilage in rheumatoid arthritis. PMID: 23137648
- The serine protease tissue plasminogen activator (tPA) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5, were identified as Reelin cleaving enzymes. PMID: 23082219
- study showed that ADAMTS-1, -4, -5 and TIMP3 were expressed at differential levels in hepatocellular carcinoma cell lines PMID: 22735305
- Data suggest that cleavage of aggrecan by matrix metalloproteinases in knee cartilage from injured or osteoarthritic subjects is low compared with cleavage by aggrecanase-1 (at least early in osteoarthritis, as suggested by other evidence). PMID: 22670872
- results suggest that during the acute phase after knee injury there is an increased aggrecanase activity against both the interglobular domain (IGD) and the CS2 cleavage sites of joint cartilage aggrecan PMID: 21664283
- Data show that the expression of ADAMTS4, 9, 16 and was up-regulated during chondrogenesis, ADAMTS1 and 5 were down-regulated. PMID: 22562232
- Suggest IL-6 may participate in cartilage destruction in rheumatoid arthritis as an inducer of ADAMTS-4 expression from synoviocytes. PMID: 22324945
- Multiple matrix metalloproteinases and ADAMTS-4 are involved in the natural history of interverteral lumbar disc herniation. PMID: 20857147
- Serum ADAMTS4 levels are associated with the presence and the severity of coronary artery disease. PMID: 21946608
- ADAMTS-4 is present in human coronary atherosclerotic plaques. PMID: 21345877
- effect of transforming growth factor-beta (TGF-beta) on ADAMTS-4 expression in macrophages along with the regulatory mechanisms underlying its actions PMID: 21334453
- Patients with acute coronary syndrome showed increased ADAMTS4 expression, which may aggravate the development of atherosclerosis and instability of atherosclerotic plaques. PMID: 20625753
- ADAMTS4 expression was found to be regulated by EWS-FLI1 fusion gene-dependent manner. ADAMTS4 protein was highly expressed in tumor samples of the patients with EWS by using immunohistochemistry. PMID: 20664926
- Plasma ADAMTS4 was measured in stable-effort angina pectoris, acute coronary syndrome & controls. The pattern of its release was clearly different in various forms of ACS. It showed a weak correlation with high-sensitivity C-reactive protein. PMID: 19944557
- The C-terminal domains of ADAMTS-4 and ADAMTS-5 affect the structure around the active site, favouring interaction with TIMP-3. PMID: 19643179
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix.
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組織特異性：Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2: Detected in osteoarthritic synovium.
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