ADAMTS12 Antibody

中文名稱：

ADAMTS12兔多克隆抗體
貨號：

CSB-PA001300LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001300LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ADAMTS12 Polyclonal antibody
Uniprot No.：

P58397
基因名：

ADAMTS12
別名：

ADAMTS12 antibody; UNQ1918/PRO4389A disintegrin and metalloproteinase with thrombospondin motifs 12 antibody; ADAM-TS 12 antibody; ADAM-TS12 antibody; ADAMTS-12 antibody; EC 3.4.24.- antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12 protein (26-229AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ADAMTS12 Antibody (CSB-PA001300LA01HU)，的標記方式是Non-conjugated。對于ADAMTS12 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA001300LB01HU	ADAMTS12 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001300LC01HU	ADAMTS12 Antibody, FITC conjugated
Biotin	CSB-PA001300LD01HU	ADAMTS12 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.
基因功能參考文獻：
1. ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. PMID: 29135310
2. ADAMTS12 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
3. Decreased levels of ADAMTS-12 were found to be associated with intrahepatic cholestasis of pregnancy. PMID: 26363034
4. ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review] PMID: 24876675
5. ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis. PMID: 23019333
6. Our results suggest that ADAMTS12 may be a susceptibility gene for RA development. PMID: 22505177
7. statistically significant increase in mRNA expression of ADAMTS-7 and ADAMTS-12 was observed in the endplate cells in degenerative discs compared with nondegenerative discs PMID: 22247065
8. The data supported the hypothesis that genetic variations in ADAMTS12 influence the risk of schizophrenia. PMID: 22322903
9. expression of ADAMTS12 in colorectal cancer stroma plays an important role in inhibiting tumor development PMID: 21559743
10. This study identifies a novel biological role for ADAMTS-12, and highlights the importance and complexity of its non-proteolytic domain(s) pertaining to its function. PMID: 21494557
11. ADAMTS-12 is a new COMP-interacting and -degrading enzyme and thus may play an important role in the COMP degradation in the initiation and progression of arthritis PMID: 16611630
12. data suggest that ADAMTS12 confers tumour-protective functions upon cells that produce this proteolytic enzyme PMID: 17895370
13. ADAMTS-7 and ADAMTS-12 are newly identified enzymes responsible for cartilage oligomeric matrix protein degradation in arthritis. PMID: 19098927
14. Results demonstrate that ADAMTS-12, a downstream molecule of PTHrP signaling, is a novel regulator of chondrogenesis. PMID: 19151918
15. ADAMTS-12 is a novel anti-tumor protease that can reduce the proliferative properties of tumor cells. PMID: 19638407
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
組織特異性：

Expressed in skeletal muscle and fat.
數據庫鏈接：

HGNC: 14605

OMIM: 606184

KEGG: hsa:81792

STRING: 9606.ENSP00000422554

UniGene: Hs.12680

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