ACYP2 Antibody

說明書

中文名稱：

ACYP2兔多克隆抗體
貨號：

CSB-PA080064
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P14621
基因名：

ACYP2
別名：

Acylphosphatase 2 antibody; Acylphosphatase 2 muscle type antibody; Acylphosphatase antibody; Acylphosphatase muscle type isozyme antibody; Acylphosphatase-2 antibody; Acylphosphatase2 antibody; Acylphosphate phosphohydrolase 2 antibody; Acylphosphate phosphohydrolase antibody; ACYM antibody; ACYP 2 antibody; ACYP antibody; Acyp2 antibody; ACYP2_HUMAN antibody; Muscle type acylphosphatase 2 antibody; muscle type isozyme antibody
宿主：

Rabbit
反應種屬：

Human,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human ACYP2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Its physiological role is not yet clear.
基因功能參考文獻：
1. the genetic polymorphisms of ACYP2 and TSPYL6 are associated with increased risk of developing ischemic stroke PMID: 27686078
2. Results found an association between the ACYP2 rs1872328 polymorphism and cisplatin-induced ototoxicity. PMID: 28445188
3. Our results indicate that ACYP2 polymorphisms may influence the GC risk and may serve as a new precursory biomarker in the northwest Chinese Han population. PMID: 28415712
4. Findings indicate significant associations between single nucleotide oolymorphism (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. PMID: 27894080
5. ACYP2 gene may be associated with an increased risk of esophageal carcinoma in Chinese Han populations. Future studies to address the biological function of this polymorphism in the development of esophageal carcinoma are warranted. PMID: 28424424
6. three SNPs in ACYP2 (rs1682111, rs11896604 and rs843720) associate with lung cancer in the Chinese Han population. PMID: 27974682
7. Genetic polymorphisms in the telomere length-related gene ACYP2 are associated with the risk of colorectal cancer in a Chinese Han population. PMID: 28039478
8. Data show that the acylphosphatase 2 (ACYP2) gene polymorphism significantly decreased the risk of high altitude pulmonary edema (HAPE). PMID: 27552709
9. Rs6713088, rs843752, and rs17045754 associated with high-altitude pulmonary edema risk PMID: 28353602
10. Results shown that the previously reported association of an ACYP2 variant with cisplatin-induced hearing loss in pediatric brain tumor patients could be replicated in an independent cohort of patients with osteosarcoma. Therefor, the ACYP2 variant should be considered a predictor of cisplatin-induced hearing loss in patients with osteosarcoma or other solid tumors PMID: 26928270
11. These findings suggest a minor role of the single nucleotide polymorphisms of ACYP2 investigated as genetic determinants of chronic oxaliplatin-induced peripheral neurotoxicity. PMID: 25858589
12. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to ototoxicity severity. PMID: 25665007
13. Enhanced stability is observed upon modifications of a loop region in the enzyme acylphosphatase and is achieved despite significant enthalpy losses. PMID: 23754389
14. The study used a stopped-flow device coupled to turbidometry detection to monitor the rapid conversion of human muscle acylphosphatase into oligomers with varying heparan sulfate and protein concentrations. PMID: 22522822
15. Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. PMID: 10542090
16. effects of 40 single point mutations on the conversion of the denatured form of the alpha/beta protein acylphosphatase (AcP) into insoluble aggregates PMID: 11799398
17. studies of aggregates formed from human muscle acylphosphatase and disaggregation suggests that amyloid formation occurs in discrete steps whose reversibility is increasingly difficult, and dependent on the size of the aggregates PMID: 15670608
18. Most of the conserved glycine residues in this protein could have been maintained during evolution because of their ability to inhibit amyloid aggregation. PMID: 16084386
19. extensive mutational analysis of aggregation and disaggregation of amyloid-like protofibrils of muscle acylphosphatase PMID: 18809411
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蛋白家族：

Acylphosphatase family
數據庫鏈接：

HGNC: 180

OMIM: 102595

KEGG: hsa:98

STRING: 9606.ENSP00000378161

UniGene: Hs.516173

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