ACVR1C Antibody

說明書

中文名稱：

ACVR1C兔多克隆抗體
貨號：

CSB-PA007118
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q8NER5
基因名：

ACVR1C
別名：

Activin A receptor; type IC antibody; Activin receptor like kinase 7 antibody; Activin receptor type 1C precursor antibody; Activin receptor type IC antibody; Activin receptor type-1C antibody; Activin receptor-like kinase 7 antibody; ACTR IC antibody; ACTR-IC antibody; ACTRIC antibody; ACV1C_HUMAN antibody; Acvr1c antibody; ACVRLK7 antibody; ALK 7 antibody; ALK-7 antibody; ALK7 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human ACTR-IC.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應用范圍：

IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:20000

Protocols：

Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
基因功能參考文獻：
1. reduced expression in sensitive skin; plays crucial roles in the pathogenesis of sensitive skin PMID: 26836979
2. Loss of ALK7 expression are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma. PMID: 26406402
3. Alk7 is expressed in male germ cells and Sertoli cells. PMID: 26289399
4. ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer. PMID: 23793810
5. Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients. PMID: 23765385
6. reduction or lack of ALK7 expression may account for the loss of its ligand sensitivity of breast cancer cells, thereby leading to breast tumor progression. PMID: 22086737
7. These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. PMID: 21356369
8. cDNA cloning, expression studies and chromosome mapping PMID: 12063393
9. ALK7 and its isoforms are expressed in human placentae of different stages of pregnancy and that their expression is developmentally regulated PMID: 12606401
10. ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components PMID: 15107418
11. the Nodal-ALK7 pathway inhibits cell proliferation by inducing G(1) cell cycle arrest PMID: 15150278
12. AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. PMID: 15196700
13. ALK7-induced apoptosis is at least in part through two Smad-dependent pathways, Bax/Bcl-2 and Xiap. PMID: 16603637
14. GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID: 18480259
15. The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2. PMID: 18784254
16. One of the direct target genes in the ALK7 signaling pathway is the insulin gene in pancreatic beta-cells, and that PDX-1 is directly involved in this pathway through interaction with Smad2 and Smad3. PMID: 18951876
17. Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 was adipose tissue specific. PMID: 19275893
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
組織特異性：

Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
數(shù)據(jù)庫鏈接：

HGNC: 18123

OMIM: 608981

KEGG: hsa:130399

STRING: 9606.ENSP00000243349

UniGene: Hs.562901

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