ACAT1 Antibody
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中文名稱：ACAT1兔多克隆抗體
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貨號：CSB-PA000796
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規格：￥1090
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圖片：
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Western Blot analysis of A549 cells using ACAT-1 Polyclonal Antibody -
Western Blot analysis of HuvEc MCF7 HELA cells using ACAT-1 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：ACAT1
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別名：ACAT 1 antibody; ACAT antibody; acat1 antibody; Acetoacetyl CoA thiolase antibody; acetoacetyl Coenzyme A thiolase antibody; Acetoacetyl-CoA thiolase antibody; Acetyl CoA acetyltransferase; mitochondrial antibody; Acetyl Coenzyme A acetyltransferase 1 antibody; Acetyl-CoA acetyltransferase antibody; acetyl-coa acetyltransferase precursor; mitochondrial antibody; Acetyl-CoA thiolase; mitochondrial antibody; acetyl-Coenzyme A acetyltransferase 1 antibody; MAT antibody; mitochondrial acetoacetyl-CoA thiolase antibody; mitochondrial antibody; RATACAL antibody; T2 antibody; testicular tissue protein Li 198 antibody; THIL antibody; THIL_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human ACAT-1.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.
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基因功能參考文獻：
- High ACAT1 expression is associated with breast cancer. PMID: 30092298
- Insulin promotes progression of colon cancer by upregulation of ACAT1. PMID: 29793481
- ACAT1 exonic mutations that affect ESE sequences may result in aberrant splicing. This may affect the activity of mitochondrial acetoacetyl-CoA thiolase. PMID: 27748876
- compound heterozygous of ACAT1 gene mutations probably underlie the beta-ketothiolase deficiency in our patient PMID: 27264805
- Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms. PMID: 25639359
- the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3 PMID: 24486017
- these findings indicate that ACAT1 expression could serve as a potential prognostic marker in prostate cancer, specifically in differentiating indolent and aggressive forms of cancer. PMID: 24311408
- ACAT1 expression is substantially elevated in human castration-resistant metastatic prostate cancer tissues. PMID: 23443136
- Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
- We herein identified a common mutation, R208X, in Vietnamese patients. We identified R208X homozygously in six patients and heterozygously in two patients among eight Vietnamese patients. PMID: 20156697
- the siblings with the same T2 gene mutations present different clinical severity of T2 deficiency PMID: 20046049
- Single base substitutions at the initiator codon produced wild-type T2 polypeptide to various degrees PMID: 12754704
- mild mutations (A132G, D339-V340insD) retained some residual T2 activity PMID: 15128923
- Cloning and sequencing long range PCR products revealed a 6.4kb deletion. Alu element-mediated unequal homologous recombination between an Alu-Sx in intron 1 and another Alu-Y in intron 4 appears to be responsible for this deletion. PMID: 16935016
- E252del is a temperature-sensitive K(m) mutant. PMID: 17236799
- Crystallographic and kinetic studies were made on mitochondrial acetyl-CoA thiolase: the importance of potassium and chloride ions were noted for its structure and function. PMID: 17371050
- A point mutation was responsible for the aberrant RNA splicing of the mitochondrial acetoacetyl-CoA thiolase gene. PMID: 18511318
- sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not PMID: 18562306
- I/D polymorphism of ACE gene and AC AT1 gene influence the development of hypertension and Left Ventricular Hypertrophy in Hemodialysis patients. PMID: 19112833
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相關疾病：3-ketothiolase deficiency (3KTD)
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亞細胞定位：Mitochondrion.
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蛋白家族：Thiolase family
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數據庫鏈接：
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