A2ML1 Antibody

Name: A2ML1 Antibody
Brand: CUSABIO
SKU: CSB-PA001005LA01HU

說明書

中文名稱：

A2ML1兔多克隆抗體
貨號：

CSB-PA001005LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: A2ML1 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 162, 106 kDa
Observed band size: 162 kDa

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA001005LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

The A2ML1 antibody is generated from the rabbit immunized with a partial recombinant protein corresponding to 625-751 amino acids of human A2ML1 protein. It exhibits the unconjugated IgG isoform. Its specificity for human A2ML1 protein has been validated in ELISA, IHC, and WB applications. The purity of this A2ML1 antibody is greater than 95% using protein G purified.

Its target protein A2ML1 mainly inhibits protease activity, contributing to protecting tissues from degradation by enzymes. A2ML1 also plays a role in several biological processes, including immune response, wound healing, and tissue regeneration. Mutations in the A2ML1 gene have been associated with several developmental disorders, including Noonan syndrome-like disorder with loose anagen hair.
產品名稱：

Rabbit anti-Homo sapiens (Human) A2ML1 Polyclonal antibody
Uniprot No.：

A8K2U0
基因名：

A2ML1
別名：

A2ML1 antibody; CPAMD9Alpha-2-macroglobulin-like protein 1 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Alpha-2-macroglobulin-like protein 1 protein (625-751AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，A2ML1 Antibody (CSB-PA001005LA01HU)，的標記方式是Non-conjugated。對于A2ML1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA001005LB01HU	A2ML1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001005LC01HU	A2ML1 Antibody, FITC conjugated
Biotin	CSB-PA001005LD01HU	A2ML1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
基因功能參考文獻：
1. The functional assessment supported the pathogenicity of the RAF1 and RIT1 variants of unknown significance (VUSs), while the significance of two VUSs in A2ML1 remained unclear. PMID: 29402968
2. The indigenous Filipino population has a ~50% prevalence of otitis media. A2ML1 genotype is the primary risk factor for otitis media and main determinant of disease progression, although age, the middle ear microbiome, and social clusters might modulate the effect of the A2ML1 genotype. PMID: 27484237
3. A2ML1-related otitis media susceptibility may be mediated by changes in the middle ear microbiome. PMID: 27799062
4. Studies support a role for alpha-2-macroglobulin-like 1 protein (A2ML1) in the pathophysiology of otitis media. PMID: 26121085
5. our results provide evidence that mutations in A2ML1 are a cause of Noonan-like syndrome, with a variable phenotype ranging from severe to very mild. PMID: 24939586
6. a new class of target antigens in a paraneoplastic autoimmune multiorgan syndrome PMID: 20805888
7. alpha2ML1 is the first alpha2macroglobulin family member detected in the epidermis, where it may play an important role during desquamation by inhibiting extracellular proteases. PMID: 16298998
8. alpha2ML1 binding to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis PMID: 18648652
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亞細胞定位：

Secreted.
蛋白家族：

Protease inhibitor I39 (alpha-2-macroglobulin) family
組織特異性：

In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.
數據庫鏈接：

HGNC: 23336

OMIM: 610627

KEGG: hsa:144568

STRING: 9606.ENSP00000299698

UniGene: Hs.620532

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