S100B Monoclonal Antibody
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中文名稱：S100B鼠單克隆抗體
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貨號(hào)：CSB-MA106771A0m
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規(guī)格：￥1320
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：S100B單克隆抗體（CUSABIO貨號(hào)：CSB-MA106771A0m）是針對(duì)神經(jīng)膠質(zhì)細(xì)胞特異性標(biāo)志物S100B蛋白研發(fā)的小鼠源單克隆抗體，適用于人源樣本的ELISA檢測(cè)。S100B是一種鈣結(jié)合蛋白，主要分布于中樞神經(jīng)系統(tǒng)的星形膠質(zhì)細(xì)胞，在維持神經(jīng)元功能、調(diào)控炎癥反應(yīng)及細(xì)胞增殖中起重要作用，其表達(dá)水平與腦損傷、神經(jīng)退行性疾病（如阿爾茨海默病）及黑色素瘤等腫瘤進(jìn)程密切相關(guān)，是神經(jīng)科學(xué)和腫瘤研究領(lǐng)域的熱門生物標(biāo)志物。本產(chǎn)品經(jīng)ELISA驗(yàn)證具有高靈敏度和特異性，可精準(zhǔn)識(shí)別天然構(gòu)象的S100B蛋白，適用于腦脊液、細(xì)胞裂解液等樣本中S100B的定量分析，為神經(jīng)損傷機(jī)制研究、腫瘤微環(huán)境探索及疾病模型構(gòu)建提供可靠工具。該抗體采用嚴(yán)格質(zhì)控工藝生產(chǎn)，確保批次間穩(wěn)定性，滿足科研場(chǎng)景中高通量篩選、生物標(biāo)志物發(fā)現(xiàn)及分子互作研究需求，是神經(jīng)病理學(xué)、腫瘤免疫學(xué)等領(lǐng)域的理想選擇。
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產(chǎn)品名稱：mouse anti-Homo sapiens (Human) S100B monoclonal antibody
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Uniprot No.：
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基因名：
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別名：NEF antibody; Protein S100 B antibody; Protein S100-B antibody; S 100 calcium binding protein beta chain antibody; S 100 protein beta chain antibody; S-100 protein beta chain antibody; S-100 protein subunit beta antibody; S100 antibody; S100 calcium binding protein beta (neural) antibody; S100 calcium-binding protein B antibody; S100 protein beta chain antibody; S100B antibody; S100B_HUMAN antibody; S100beta antibody
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宿主：mouse
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反應(yīng)種屬：Human
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免疫原：Recombinant Human S100B protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：monoclonal
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抗體亞型：IgG1
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純化方式：>95%,protein G purifed
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克隆號(hào)：1A1B1
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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產(chǎn)品提供形式：liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
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基因功能參考文獻(xiàn)：
- rs9722, a functional SNP in the 3'-UTR of the S100B gene, was strongly associated with age of onset of Parkinson's disease. PMID: 29529989
- The S100B gene rs9722 polymorphism may contribute to the susceptibility of IS. PMID: 29343763
- It is unclear if the higher S100B concentration in football players playing at least 50 plays was caused by exercise or impacts. Therefore, if serum S100B is to be used as a biomarker of impacts, and possible brain injury in sport, exercise time and intensity should be taken into account as confounding variables. PMID: 30203865
- High S100B expression is associated with chemoresistance in ovarian cancer. PMID: 29956807
- The serum levels of S100B in Groups A and B rose after the injury and reached a peak on the 4th day of injury. Serum levels of NSE and S100B protein can reflect the degree of spinal cord injury. PMID: 29959890
- Serum levels of S100B (and neuron-specific enolase) at admission were related to initial Glasgow Coma Scale (GSC) scores, and these levels one week after traumatic brain injury were related to six month GSC scores. PMID: 30257306
- Studied use of serum S100B as a biomarker to predict injury in patients with mild head injury. Found patients with cranial injury detected by CT, had higher S100B protein levels than those without cranial injury. PMID: 29850551
- The expression of serum S100beta in patients with postoperative cognitive dysfunction was significantly increased PMID: 28537663
- A high S100B expression is associated with a good prognosis in patients with p53 mutant and p53 wild-type breast cancers. PMID: 29345293
- S100B may have a role in pathogenesis of schizophrenia; patients show higher plasma levels of S100B than healthy controls PMID: 27279465
- We investigated the possible correlation between TCD results and S100B, NSE and LDH levels as well as between NSE-LDH and S100B-LDH levels by regression analysis. We found a statistically significant relationship for both NSE, S100B with LDH. PMID: 29244749
- Results showed that our prepared S100B mAbs were suitable for detecting S100B expression in human tissues, furnishing promising tools for further functional investigation and clinical applications. PMID: 28849099
- In this study demonstrated that S100b is elevated in Alzheimer disease cases. and the increased levels in African Americans here may be indicative of increased severity in specific populations. PMID: 28582866
- In neonates, NSE and s100B levels increase after bypass surgery and return below preoperative baseline levels by postoperative day seven. The levels of s100B were positively correlated with circulatory arrest time and negatively correlated with age at time of surgery. PMID: 28571730
- the serum levels of S100B protein mediated the association between S100B gene polymorphism and scene selectivity in the retrosplenial cortex PMID: 26733530
- There is a significant correlation between mortality in the critically ill patients in the intensive care unit and increased serum concentration of S100B and NSE. PMID: 29222857
- Our findings showed that both S100beta and NSE levels similarly increased during CPB and immediately after CPB during sevoflurane and propofol based anesthesia. PMID: 26856295
- This study demonstrated that S100A12 mRNA levels were significantly decreased in the new cases of untreated MS patients in comparison to healthy controls. PMID: 28433998
- Increased serum levels of S100B protein (and NSE) were observed postoperatively in patients with postoperative cognitive dysfunction. PMID: 27433840
- high S100B expression in Multiple Sclerosis (MS) patient samples suggests its usefulness as a diagnostic biomarker for MS. PMID: 26184632
- the underlying mechanism of S100B-mediated effects on cancer stem-like cell stemness was not dependent on its binding with a receptor for advanced glycation end products (RAGE), but might be through intracellular regulation, through the inhibition of p53 expression and phosphorylation. PMID: 27501952
- Data show that a high serum S100beta protein level, hypertension, and high low density lipoprotein-cholesterol (LDL-C) level were the independent risk factors for cerebral small vessel disease (SVD). PMID: 28143956
- the serum concentrations of S100B are increased in bipolar disorder patients. PMID: 27475892
- Levels of NSE and S100B are still elevated 1 year postpartum in women who have had preeclampsia in contrast to women with previous normal pregnancies. PMID: 27653032
- In vitro experiments using repeated freeze-thaw procedures showed an intracellular up-regulation of S100B in normal and vitiligo melanocytes before an extensive release in the environment. PMID: 28212812
- Acute paranoid schizophrenia inpatients present a day/night change of S100B serum levels at admission that disappears at discharge. PMID: 28188811
- Results show that S100beta protein levels are increased in childhood-onset SLE with cognitive impairment suggesting that elevated S100beta protein levels were associated with cognitive impairment. PMID: 28394234
- Compared to the control, the S100B/GAPDH mRNA ratio was significantly decreased in chronic liver diseases (p = 0.006) and most decreased in chronic hepatitis C patients (p = 0.023). We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively. PMID: 27255110
- results indicate there were decreased S100B serum levels in bipolar patients in a manic phase after treatment. PMID: 28088747
- Studies indicate that S100 calcium binding protein B protein (S100B) has high affinity for zinc (Zn2+). PMID: 27430886
- S100beta has potential as a new surveillance tool for patients with ER-positive breast cancer to monitor endocrine therapy. PMID: 28399921
- For patients recruited PMID: 28419114
- Our study provides information on the dynamic changes of MMP-9-TIMP-1 system and S100B in the perioperative period. Preoperative reduction of TIMP-1 might be predictive for shunt requirement but future studies are required for verification. PMID: 27121520
- this study shows that low levels of S100B correlate to a better anti-CTLA-4 immunotherapy response and survival in advanced melanoma patients PMID: 27728898
- Our data suggest that elevated S100B protein levels might indicate neuronal damage in the brains of people with cannabis use disorder. PMID: 26624020
- The strong CD68 and S100 co-expression in our case did not allow a clear-cut discrimination between the immunophenotype of histiocytic neoplasms and amelanotic melanoma, because of CD68 immunoreactivity occurring in 75% of metastatic malignant melanomas PMID: 26407839
- Cognitive deterioration could not be predicted using perioperative embolic load and S-100beta changes after carotid revascularization. PMID: 27395808
- Serum S100B protein levels increased after general anaesthesia. The values of S100Bp (median 164.0 ng/L) were significantly higher than the values of S100Bb (median 94.5 ng/L). The median of the difference between S100Bp and S100Bb was 58.0 ng/L. There were statistically significant differences between S100Bb and S100Bp. PMID: 26969427
- Although an elevation in S100B was not observed in this (second) ascent during re-exposure to the hypobaric hypoxia of high altitude for either the non-treated (acclimatised) or the dexamethasone treated (acclimatised and dexamethasone) groups, the hypothesis that S100B would reduce following acclimatisation could not be statistically confirmed in our study given the wide confidence intervals and small sample size PMID: 26924650
- Serum S100B is a useful quantitative biomarker in routine follow-up of high-risk melanoma patients. PMID: 26819111
- serum levels may be correlated with the carbon monoxide poisoning and could be biomarker for early diagnosis and treatment monitoring PMID: 25925764
- Our results support the hypothesis that S-100beta is an important biological indicator of HIE and serum S-100beta levels can be used as a reference index to assess hypoxic-ischemic encephalopathy severity. PMID: 26600537
- There was no association found between serum and CSF S100B with radiographic vasospasm or DIND. S100B is a potential prognostic marker for aSAH outcome PMID: 27007976
- Fetuses of active smoker mothers had lower cord blood S100B levels compared to fetuses of non-smoker mothers. PMID: 24668715
- This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients. PMID: 26421286
- Studied circulating S100B and adiponectin in children who underwent open heart surgery. S100B showed a significant increase from hospital admission up to 24 h after procedure. PMID: 26417594
- Concentrations of serum S100B protein in brain-dead organ donors are extremely high and may support the diagnosis of brain death. PMID: 26401738
- long-term exposure to high blood glucose concentrations leads to an increase in total oxidant in patients with diabetic ketoacidosis ( and that the neurotransmitter changes that develop in response to this exposure lead to an increase in S100B levels PMID: 26316432
- plasma biomarkers S100-B and copeptin did not improve prediction of poor outcome following seizure PMID: 25849778
- S100B serum levels are elevated in cerebral small vessel disease patients. PMID: 25990800
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亞細(xì)胞定位：Cytoplasm. Nucleus.
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蛋白家族：S-100 family
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組織特異性：Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
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