PRL Monoclonal Antibody

說明書

中文名稱：

PRL鼠單克隆抗體
貨號：

CSB-MA0187241A0m
規格：

￥1320
圖片：
Immunohistochemical of paraffin-embedded human breast cancer using CSB-MA0187241A0m at dilution of 1:200
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

【人源PRL單克隆抗體CUSABIO貨號：CSB-MA0187241A0m】該產品為靶向催乳素（PRL，Prolactin）的高特異性單克隆抗體，適用于人源樣本的科學研究。PRL是一種由垂體前葉分泌的多肽激素，除調控哺乳期乳汁分泌外，還參與生殖系統調節、免疫應答及代謝平衡等生理過程，其異常表達與垂體瘤、高泌乳素血癥等疾病密切相關。本抗體采用雜交瘤技術制備，經嚴格驗證可兼容酶聯免疫吸附試驗（ELISA）和免疫組織化學（IHC）兩大實驗平臺，具備優異的批間穩定性和抗原結合能力，適用于體外培養細胞、組織切片等樣本中PRL蛋白的定位與定量分析。在生殖內分泌研究、腫瘤微環境分析以及代謝性疾病機制探索等科研領域具有重要應用價值，為研究者提供可靠的工具抗體。核心關鍵詞：PRL單克隆抗體、人源催乳素檢測、ELISA/IHC抗體、垂體激素研究、雜交瘤技術抗體。
產品名稱：

mouse anti-Homo sapiens (Human) PRL monoclonal antibody
Uniprot No.：

P01236
基因名：

PRL
別名：

PRL antibody; Prolactin antibody; PRL antibody
宿主：

mouse
反應種屬：

Human
免疫原：

Recombinant Human PRL
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

monoclonal
抗體亞型：

IgG1
純化方式：

>95%,protein G purifed
克隆號：

4A2B3
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Prolactin acts primarily on the mammary gland by promoting lactation.
基因功能參考文獻：
1. Circulating prolactin levels may not be higher in patients with Behcet's disease than in controls (meta-analysis). PMID: 29412808
2. Cin85-deficient mother mice had reduced pituitary hormone prolactin secretion as a result of excessive dopamine signaling in the brain. Their offspring matured normally and produced their own pups; however, nurturing behaviors such as pup retrieval and nursing were strongly inhibited. PMID: 29158391
3. PRL levels were lower in psychogenic non-epileptic seizure patients with a history of sexual abuse compared to healthy controls and healthy controls with a history of sexual abuse. PMID: 28927333
4. In newborns, serum PRL and hGH levels show a positive correlation that can be explained by common regulatory factors or a drift phenomenon. A higher gestational week is associated with a higher PRL/hGH ratio. PMID: 28700563
5. High normal circulating prolactin levels predict changes in haemodynamic indices and worsening endothelial function in healthy postmenopausal women. Particularly in young postmenopausal women, prolactin predicts accelerated arterial stiffening. PMID: 28332508
6. In conclusion, the present study provides evidence supporting a significantly positive association between plasma prolactin levels and the risk of breast cancer. PMID: 27184120
7. Our studies have demonstrated the essential role of endogenous PRL and CDK7 in the upregulation of PRLR by E2 and provide insights for therapeutic approaches that will mitigate the transcription/expression of PRLR and its participation in breast cancer progression fueled by E2 and PRL via their cognate receptors. PMID: 28423697
8. GABA alpha2 and/or alpha3 receptor subtypes are involved in GABAergic modulation of prolactin secretion. PMID: 27128218
9. This study revealed a significant association between the prolactin polymorphic variant rs1341239 and the development of hyperprolactinemia in patients with schizophrenia. PMID: 27776952
10. High serum prolactin and vasoinhibin levels predict and may impact retinopathy of prematurity progression PMID: 27842054
11. The production of PRL by Mvarphis was increased by unknown components of rheumatoid arthritis and rheumatoid arthritis synovial fluid, where it could contribute to disease progression. PMID: 28642278
12. findings show that cysteine in the PRL catalytic site is endogenously phosphorylated as part of the catalytic cycle and that phosphocysteine levels change in response to Mg(2+) levels. PMID: 27856537
13. Depression and anxiety in subfertile males are associated with higher secretion of PRL. PMID: 28456148
14. Prolactin rs1341239 T allele decreases the risk of brick tea fluorosis in the Inner Mongolia in China population. PMID: 28152004
15. In breast cancer, PRL hormone and its signaling pathway may play an important role in maintaining tumor differentiation state and in turn better patient outcome. PMID: 26980025
16. Data indicate 12 single nucleotide polymorphism (SNPs) associated with increased prolactin levels in both plasma and cerebrospinal fluid (CSF). PMID: 27357110
17. these data strongly support a critical interplay between prolactin and estrogen via PAK1 and suggest that ligand-independent activation of ERalpha through prolactin/PAK1 may impart resistance to anti-estrogen therapies. PMID: 26944939
18. These data provide insight into the mechanisms guiding PRL-mediated breast cancer cell motility and invasion and highlight a significant role for phosphoTyr-PAK1 in breast cancer metastasis. PMID: 27542844
19. changes in mRNA expression of selected toll-like receptors (TLR2, TLR4, TLR7), stress cytokine prolactin (PRL), and proand anti-inflammatory cytokines (TNF-alpha, IL-6, IL-12, IL-10) in peripheral blood monocytes of celiac disease patients, were investiagted. PMID: 28028951
20. The review focuses on the role of prolactin in breast development, bone homeostasis and in breast cancer to bone metastases. (Review) PMID: 27782069
21. Study demonstrate that PRL is necessary for the survival of (retinal pigment epithelium) RPE under normal and advancing age conditions and, identified SIRT2 and TRPM2 as molecular targets for the antioxidant and antiapoptotic actions of PRL in the RPE. PMID: 27322457
22. This review addresses risk factors for rheumatoid arthritis (RA) linked to prolactin (PRL), the effects of PRL and vasoinhibins on joint tissues, blood vessels, and immune cells, and the clinical and experimental data associating PRL with RA. [review] PMID: 27026299
23. Data suggest that the serum level of PRL was closely related to the antibody production and disease activity of systemic lupus eruthematosus patients. PRL concentration was dramatically reduced upon the remission of disease activity. PMID: 26678441
24. prolactin levels and pituitary adenoma diameters may be associated with increased risk of cancer in patients with prolactinoma PMID: 26720589
25. reduction in prolactin level is frequent after SRS and FSRT for prolactinomas; however, true biochemical remission is uncommon. PMID: 25410143
26. the -1189 estrogen response element is the dominant response element involved in the human PRL transcriptional response. PMID: 26691151
27. Data suggest that plasma kisspeptin and serum prolactin levels may be involved in the physiopathology of breast enlargement in newborns. PMID: 26831552
28. Serum PRL was significantly higher in chronic hepatitis C patients compared to controls. PMID: 25912488
29. PAK1 nuclear translocation is ligand-dependent: only PRL but not E2 stimulated PAK1 nuclear translocation PMID: 27003261
30. Mean serum prolactin level was higher in the patients with recurrent miscarriage than in healthy women. PMID: 26370377
31. findings revealed that the -1149TT genotype was correlated with higher levels of prolactin in serum and prolactin gene expression in peripheral blood mononuclear cells in women with systemic lupus erythematosus; study suggests that the -1149TT genotype may be a risk factor for lupus PMID: 26583155
32. The results of our study suggest the association between vitamin D status and elevated macroprolactin levels in premenopausal women. PMID: 26179930
33. Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant. No relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL % was found. PMID: 26091810
34. PRL is ectopically activated in a subset of very aggressive lung tumors, associated with a rapid fatal outcome, in a cohort of 293 lung tumor patients and in an external independent series of patients; analysis of the PRL transcripts in lung tumors and cell lines revealed systematic truncations of their 5' regions, including the signal peptide-encoding portions. PMID: 24512221
35. PRL-PRLR can escalate the impact of breast cancer on bone metastasis and the presence of PRLR in the tumor microenvironment of breast cancer bone metastasis has the potential to modulate the microenvironment to induce lytic osteoclast formation. PMID: 26586670
36. Women with higher prolactin levels did not report significantly increased hostility. PMID: 25226401
37. results suggest that up-regulation of IL-10 by prolactin might be modulating the pro-inflammatory response against mycobacterial antigens through the MAPK pathway PMID: 25218920
38. there is a link between prolactin and mean platelet volume levels; in women with PCOS, elevated PRL levels may increase the risk of developing atherothrombotic events via the activation of platelets PMID: 25359296
39. Our data extends prior research linking prolactin and invasive breast cancer to the outcome of in situ breast tumours and shows that higher circulating prolactin is associated with increased risk of in situ breast cancer. PMID: 25887963
40. Cord blood prolactin level showed weak correlation with duration of full obstetric delivery, and duration of the second stage. PMID: 26160091
41. the prolactin -1149 G/T polymorphism is associated with susceptibility to RA, but not SLE, in Caucasians [meta-analysis] PMID: 25724680
42. Patients with diabetes mellitus and impaired renal function demonstrate a high urinary PRL excretion. PMID: 26299069
43. serum levels were found to be higher in the infertile women than in controls PMID: 25345488
44. The prevalence and predictors of hyperprolactinemia in 178 patients with liver cirrhosis of different etio-logies, were investigated. PMID: 24816831
45. Studied the serum prolactin, cortisol, and ACTH stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects. PMID: 25243181
46. Report positive association between prolactin levels and the damage index (overall and its renal and cardiac/peripheral vascular domains), independently of other well-known risk factors in systemic lupus erythematosus. PMID: 24718588
47. Hypertensive postmenopausal women with low risk for cardiovascular diseases have increased levels of prolactin, suggesting a possible role in the pathogenesis of hypertension PMID: 24861467
48. a gene signature based on PRL-upregulated genes was associated with prolonged relapse-free and metastasis-free survival in breast cancer patients. PMID: 23758962
49. REVIEW: Hypothalamic pituitary adrenal axis and prolactin abnormalities in suicidal behavior PMID: 24040800
50. PRL constrains tumor-promoting liver inflammation. PMID: 25049387
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亞細胞定位：

Secreted.
蛋白家族：

Somatotropin/prolactin family
數據庫鏈接：

HGNC: 9445

OMIM: 176760

KEGG: hsa:5617

STRING: 9606.ENSP00000302150

UniGene: Hs.1905

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