PGC Monoclonal Antibody

說明書

中文名稱：

PGC鼠單克隆抗體
貨號：

CSB-MA112991A0m
規格：

￥1320
圖片：
Immunohistochemical of paraffin-embedded human gastric cancer tissue using CSB-MA112991A0m at dilution of 1:200
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

PGC單克隆抗體（CUSABIO貨號：CSB-MA112991A0m）是針對胃蛋白酶原C（Pepsinogen C）的科研用免疫試劑，該靶標蛋白作為胃部消化酶前體在胃黏膜功能研究中具有重要價值。本產品采用雜交瘤技術制備，經特異性驗證可識別人源PGC蛋白表位，適用于酶聯免疫吸附（ELISA）和免疫組化（IHC）兩大實驗平臺。其種屬特異性經過嚴格驗證，確保對人源樣本檢測的可靠性，能夠有效支持胃蛋白酶原代謝調控、胃黏膜細胞分化等基礎研究，為消化系統疾病機制探索提供高質量的抗體工具。該抗體在胃功能相關蛋白組學分析、病理切片標記等科研場景中展現優異性能，是開展胃蛋白酶原家族研究的關鍵試劑。
產品名稱：

mouse anti-Homo sapiens (Human) PGC monoclonal antibody
Uniprot No.：

P20142
基因名：

PGC
別名：

Gastricsin antibody; PEPC antibody; PEPC_HUMAN antibody; pepsin C antibody; Pepsinogen C antibody; pepsinogen group II antibody; PGC antibody; PGII antibody; preprogastricsin antibody; Progastricsin antibody
宿主：

mouse
反應種屬：

Human
免疫原：

Recombinant Human PGC
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

monoclonal
抗體亞型：

IgG1
純化方式：

>95%,protein G purifed
克隆號：

1G1H3
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Hydrolyzes a variety of proteins.
基因功能參考文獻：
1. Recombinant pepsin C and pepsinogen C were purified from transgenic rice culture medium, and the NH2-terminal 5-residue sequences were verified by amino acid sequencing. PMID: 29108629
2. serum levels correlated with age, sex and the level of Helicobacter pylori infection PMID: 27865295
3. Pepsinogen-II 100 bp ins/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia. PMID: 26486507
4. Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer. PMID: 25857852
5. Data show that SNP interactions among H. pylori-related genes PGC, PTPN11, and IL1B, are associated with susceptibility to gastric carcinogenesis. PMID: 26158864
6. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured.[Pepsinogen I, Gastrin 17] PMID: 22066020
7. The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer. PMID: 25551587
8. Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication. PMID: 25028655
9. High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions. PMID: 24895149
10. An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer. PMID: 24586594
11. plasma PG II level significantly correlated with H. pylori-infected gastric cancer PMID: 23326145
12. High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis. PMID: 24009139
13. Levels of pepsinogen/pepsin A and C are higher in the mouth swabs of infants with clinical gastroesophageal reflux. PMID: 23311720
14. PGC rs6458238, PGC rs4711690 and PTPN11 rs12229892 were associated with susceptibilities to atrophic gastritis and/or gastric cancer. PMID: 23455381
15. Data suggest that serum pepsinogen I/II ratio (pepsinogen A/C ratio) is correlated with diabetic nephropathy and thus may be a biological marker for degree of urinary albumin excretion in patients with type 2 diabetes. PMID: 23047493
16. The serum levels of PG II and G-17 were significantly higher in Changle than those in Fuan. PMID: 23117263
17. Data suggest that subjects with higher PGI level, and PG I/II ratio are more likely to develop several dyspeptic symptoms. PMID: 23178618
18. Serum pepsinogens I (PGI) and II (PGII), gastrin 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA) antigen among 309 consecutive patients, were measured. PMID: 22066020
19. Chinese patients with sPGII greater than 10.25 microg/L are at greater risk of various H. pylori-related gastropathies. PMID: 21303408
20. PGC gene insertion/deletion polymorphism is negatively related to PGC protein expression in gastric mucosa, but is not related to the serum PGC level. PMID: 19624876
21. Pepsinogen C insertion/deletion polymorphism and Helicobacter pylori infection seem to present a positive interaction in the development of gastric cancer. PMID: 19173902
22. Pepsinogen C is expressed in a quarter of ovarian carcinomas and might identify a subset of patients with different prognosis PMID: 12128264
23. These results suggest that there is some relation between pepsinogen C gene polymorphism and gastric cancer, and the person with homogenous allele 1 predisposes to gastric cancer more than those with other genotypes. PMID: 12508350
24. results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach PMID: 12698190
25. human cathelicidin antimicrobial peptide-18 in seminal plasma is processed to generate a 38-amino acid antimicrobial peptide ALL-38 by the prostate-derived protease gastricsin when incubated at a pH corresponding to the vaginal pH PMID: 12759353
26. Pepsinogen C can be a good indicator in the screening and diagnosis of precursor of gastric cancer and gastric cancer. PMID: 15200883
27. pepsinogen C may be expressed by uveal melanoma and suggest that this protein could be considered as a new, unfavorable prognostic factor in these tumors PMID: 15503827
28. Higher levels of Pepsinogen II is associated with early gastric cancer PMID: 15688378
29. pepsinogen C genetic variants have a role in gastric cancer PMID: 16937501
30. Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer. PMID: 17559360
31. pepsinogen C has a role in SP-B proteolytic processing in alveolar type 2 cells PMID: 18256027
32. role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients PMID: 18447628
33. pepsinogens may have a role in esophageal squamous dysplasia PMID: 18844222
34. The pepsinogen C gene polymorphism increases an individual's susceptibility to gastric cancer and its precancerous conditions PMID: 19132389
35. Decreased pepsinogen I/II ratio is a reliable marker for atrophy in the stomach corpus. PMID: 19731026
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亞細胞定位：

Secreted.
蛋白家族：

Peptidase A1 family
數據庫鏈接：

HGNC: 8890

OMIM: 169740

KEGG: hsa:5225

STRING: 9606.ENSP00000362116

UniGene: Hs.1867

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