MAP2 Monoclonal Antibody

說明書

中文名稱：

MAP2鼠單克隆抗體
貨號：

CSB-MA000225
規(guī)格：

￥1090
圖片：
IHC staining of Human brain tissue paraffin-embedded, diluted at 1:200.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

CUSABIO貨號：CSB-MA000224為MAP2單克隆抗體，靶向神經(jīng)元特異性微管相關(guān)蛋白MAP2（Microtubule-Associated Protein 2），該蛋白在神經(jīng)元樹突發(fā)育、細(xì)胞骨架穩(wěn)定及突觸可塑性調(diào)控中發(fā)揮關(guān)鍵作用，是神經(jīng)細(xì)胞分化與功能研究的經(jīng)典標(biāo)記物。本產(chǎn)品經(jīng)過ELISA、免疫組化（IHC）等多平臺驗(yàn)證，具有高特異性和批次穩(wěn)定性，可識別人類、小鼠、大鼠等多種物種的MAP2蛋白，適用于腦組織切片、原代神經(jīng)元培養(yǎng)等樣本的定位與定量分析。在神經(jīng)退行性疾病機(jī)制研究（如阿爾茨海默病）、神經(jīng)發(fā)育動態(tài)觀察、體外神經(jīng)元模型構(gòu)建等科研場景中表現(xiàn)優(yōu)異，為探索神經(jīng)元形態(tài)發(fā)生、軸突導(dǎo)向及突觸網(wǎng)絡(luò)建立提供可靠工具。該抗體適用于冷凍/石蠟包埋組織切片處理，推薦與熒光二抗或HRP顯色系統(tǒng)配合使用，助力神經(jīng)科學(xué)、細(xì)胞生物學(xué)領(lǐng)域的高精度實(shí)驗(yàn)需求。
Uniprot No.：

P11137
基因名：

MAP2
別名：

DKFZp686I2148 antibody; MAP 2 antibody; MAP dendrite specific antibody; MAP-2 antibody; MAP2 antibody; MAP2A antibody; MAP2B antibody; MAP2C antibody; Microtubule associated protein 2 antibody; Microtubule-associated protein 2 antibody; MTAP2_HUMAN antibody
宿主：

Mouse
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthetic Peptide
免疫原種屬：

H, M, R
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
克隆號：

21G5
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
基因功能參考文獻(xiàn)：
1. study suggests that miR-484 and MAP2 can be utilized as predictors for the clinical diagnosis and prognosis of glioma PMID: 29480405
2. Results highlight the importance of splicing alteration in HD and suggest that MAP2 alteration contributes to dendritic atrophy. PMID: 27098187
3. The expression of MAP2 and SYP proved most relevant to neurocognitive functioning in HIV-infected patients. PMID: 26637429
4. In patients with HD, a panel using calretinin and peripherin with or without MAP-2 may be most helpful in identifying transition zones PMID: 26469323
5. Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells. PMID: 26014048
6. Study reveals the presence of two selected neuronal markers, MAP-2 and SYP mRNAs and protein expression, in eutopic endometrium and in endometriotic lesions. PMID: 26604067
7. Findings demonstrate that microtubule-associated protein 2-immunoreactivity loss is closely linked to dendritic spine pathology in schizophrenia. PMID: 25818630
8. This is the first report to analyze the correlation between ET-1-induced miRNA 133a overexpression in proteinuria resulting in MRP2 downregulation, which is a contributing factor for renal cytotoxicity. PMID: 25871823
9. the difference of only two amino acids in tau and MAP2 sequences may determine their different fates in tauopathies PMID: 26134402
10. MAP2 expression is affected by actomyosin contractility during nanotopography-directed neuronal differentiation of human embryonic stem cells PMID: 25682157
11. Prolactin significantly increased the gene expression and protein levels of MAP2 in SK-N-SH neuroblastoma cells, while no significant changes were observed in U-87MG glioblastoma cells. PMID: 25629269
12. SNCG, MAP2, SDF-1 and CXCR4 may play an important role in the carcinogenesis, progression, invasion and metastasis of gastric adenocarcinoma. PMID: 25400739
13. MAP2 expression in ovarian teratomas does not appear to have a role in predictive the development of anti-NMDAR encephalitis. PMID: 25569473
14. PP2A/striatin complex modulates microtubule dynamics by regulating MAP2 phosphorylation PMID: 25497017
15. MAP 2 is a moderately sensitive marker of haemangioblastoma PMID: 24977729
16. MAP2 may play a significant role in neurotoxicity in the Alzheimer's disease brain despite the absence of MAP2-aggregates. PMID: 24587039
17. Study suggests that many of the morphological changes detected in children's brainstems regarding distributions of HIF-1alpha and MAP-2 could be due to age differences, but in some regions these distributions are more dependent on the hypoxic conditions PMID: 24780770
18. Altered MAP2 and tau expression in mesial temporal lobe epilepsy (MTLE) and decreased tau expression in MTLE with psychosis were found. PMID: 24069608
19. MAP-2 and nestin participate in the regulation of the development of gastric tissues in human embryos. PMID: 22985576
20. Dysfunction of MAP2/tau family leads to disruption of microtubule structure and impairment of axonal transport, and eventually triggers apoptosis in neurons, which becomes an essential pathway for prion to induce the neuropathology. PMID: 22874672
21. The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn. PMID: 22403409
22. Data indicate that the decline of MAP2 is a common phenomenon in transmissible spongiform encephalopathies (TSEs), which seems to occur at an early stage of incubation period. PMID: 22272295
23. Increased MAP2 expression in malignant melanoma cells significantly inhibits tumor cell growth and neoplasm invasiveness, and induces apoptosis and cell cycle arrest. PMID: 20100193
24. The results of this study confirmed previous published data showing a schizophrenia-associated decrease in MAP2 in area 9 with no change in area 17 and no change in Huntington chorea. PMID: 20092829
25. Hyperactivation of BRAF-MEK signaling activates MAP2 expression in melanoma cells by two independent mechanisms, promoter demethylation or down-regulation of neuronal transcription repressor HES1. PMID: 19880519
26. MAP2 expression in astrocytomas is due predominantly to low molecular weight isoforms, evident in astrocytes as well as neurons; focal expression of hmw-MAP2 suggests that neuronal antigens may be expressed, particularly in high grade astrocytomas. PMID: 11922706
27. role of small cluster of charged residues in controlling filament morphology PMID: 12023276
28. beta-chains of tubulin and MAP-2 are expressed functionally in SCLC cell lines in association with the development of dendrite-like processes on PC-9 / ECM substrate PMID: 12079519
29. These results provide strong evidence suggesting that MAP2c and tau stabilize microtubules by binding along individual protofilaments, possibly by bridging the tubulin interfaces. PMID: 12082079
30. Immunoreactivity of MAP-2 has been demonstrated in most neuroendocrine and neuroectodermal related neoplasms such as small cell carcinoma, large cell neuroendocrine carcinoma, carcinoid tumor of the lung. PMID: 12605092
31. binding of dehydroepiandrosterone to MAP2C involves specific hydrogen bonds that orient the steroid into the pocket PMID: 12775713
32. The differential distribution of various epitopes suggests that the presence of the Phospho-Ser(262) epitope of tau either accelerates the transition form pre-tangle to tangle, or appears later than the other epitopes in the process of tangle formation. PMID: 12927759
33. over-expression of microtubule-associated protein 2 is associated with oral squamous cell carcinoma PMID: 14604896
34. These data point towards MAP2 as valuable diagnostic tool for pattern recognition and differential diagnosis of low-grade neuroepithelial tumors. PMID: 15146346
35. Decreased spinophilin but unchanged MAP2 expression provides molecular evidence for a hippocampal dendritic pathology in schizophrenia that preferentially affects the spines PMID: 15465982
36. determined that Fyn phosphorylated MAP-2c on tyrosine 67 PMID: 15536091
37. MAP2 is involved in the association of endoplasmic reticulum membranes with microtubules. PMID: 15623521
38. Independent of one another MAP-2c and Fyn are able to induce process outgrowth and in concert can initiate and enhance process outgrowth in an additive manner. PMID: 16145685
39. MAP-2 is expressed in the cytoplasm of non-tumorous adenohypophysial cells as well as of various pituitary adenoma types. PMID: 16195780
40. Tat action on MAP2 stability involved Tat-mediated translocation of the proteasome to the site of microtubule filaments. PMID: 16611822
41. Notch signaling, which is implicated in melanoma progression, and Hairy and Enhancer of Split (HES1) play a role in MAP2 gene regulation during melanoma progression. PMID: 16916793
42. Thus, our findings have not only identified a novel role of MAP2 in non-neuronal cells, but also provided the first implication of MAP2 in malignant oral cancer tissues. PMID: 18073143
43. Data show that the Sudden infant death syndrome group and hypoxic/ischemic group exhibites a general reduction in the number of MAP2 reactive neurons in comparison with the non-hypoxic/ischemic injury group. PMID: 19009302
44. MAP-2 immunoexpression in gliomatosis cerebri PMID: 19309409
45. In contrast with the findings of previous studies, our data indicate that MAP-2 is a moderately positive predictor of the progression of superficial spreading melanomas. PMID: 19369632
46. MAP-2 is a sensitive and specific marker of neuroblastoma, both in the primary tumor and bone marrow biopsy settings. PMID: 19701075
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亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cell projection, dendrite.
數(shù)據(jù)庫鏈接：

HGNC: 6839

OMIM: 157130

KEGG: hsa:4133

STRING: 9606.ENSP00000353508

UniGene: Hs.368281

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