IGFBP1 Monoclonal Antibody

說明書

中文名稱：

IGFBP1鼠單克隆抗體
貨號：

CSB-MA088331A0m
規格：

￥1320
圖片：
All lanes: Mouse anti- Human Insulin-like growth factor-binding protein 1 monoclonal antibody at 1μg/ml
Lane 1:Pyrolysis liquid human placental tissue 7.5μg/ml
Lane 2:Pyrolysis liquid human placental tissue 3.25μg/ml
Lane 3:IGFBP1 transfected SF9 cell lysate
Lane 4:human amniotic fluid
Secondary Goat polyclonal to Mouse IgG at 1/5000 dilution
Predicted band size : 28kd
Observed band size : 35kd
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CUSABIO貨號：CSB-MA088331A0m IGFBP1單克隆抗體是針對胰島素樣生長因子結合蛋白1（IGFBP1）研發的高特異性重組單抗，該抗體采用雜交瘤技術制備，經ELISA和Western Blot嚴格驗證，適用于人源和小鼠樣本的蛋白檢測研究。IGFBP1作為胰島素樣生長因子系統的重要調節蛋白，通過結合IGF-1/IGF-2調控其生物活性，在糖代謝、細胞增殖及胚胎發育等生理過程中發揮關鍵作用，其異常表達與妊娠糖尿病、肥胖及相關代謝綜合征密切相關。本產品采用小鼠雜交瘤細胞系生產，具有高批次穩定性和抗原結合一致性，能有效識別天然與非還原狀態下的IGFBP1蛋白，為研究代謝調控機制、妊娠相關疾病模型構建及生長發育分子網絡解析提供可靠工具。其卓越的種屬兼容性特別適合開展跨物種比較研究，在體外實驗體系中可廣泛應用于蛋白互作分析、信號通路驗證及生物標志物篩選等科研場景。該抗體已通過多種實驗體系驗證，確保在復雜生物樣本中保持低交叉反應性和高檢測靈敏度，是探索IGF系統在代謝疾病與腫瘤微環境中作用機制的重要試劑。
產品名稱：

mouse anti-Homo sapiens (Human) IGFBP1 monoclonal antibody
Uniprot No.：

P08833
基因名：

IGFBP1
別名：

AFBP antibody; Alpha pregnancy associated endometrial globulin antibody; Amniotic fluid binding protein antibody; Binding protein 25 antibody; Binding protein 26 antibody; Binding protein 28 antibody; Growth hormone independent binding protein antibody; hIGFBP 1 antibody; hIGFBP1 antibody; IBP 1 antibody; IBP-1 antibody; IBP1 antibody; IBP1_HUMAN antibody; IGF binding protein 1 antibody; IGF BP25 antibody; IGF-binding protein 1 antibody; IGFBP 1 antibody; IGFBP-1 antibody; IGFBP1 antibody; Insulin like growth factor binding protein 1 antibody; Insulin-like growth factor-binding protein 1 antibody; Placental protein 12 antibody; PP 12 antibody; PP12 antibody
宿主：

mouse
反應種屬：

Human,Mouse
免疫原：

Recombinant Human IGFBP1 Protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

monoclonal
抗體亞型：

IgG1
純化方式：

>95%,Protein G purified
克隆號：

1E1B2
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 15mmol/L NaN3Constituents: 0.1mol/L Nacl
產品提供形式：

liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
基因功能參考文獻：
1. In patients with acute myocardial infarction without previously known diabetes, high insulin-like growth factor-binding protein 1 was associated with long-term all-cause and cancer mortality but not with cardiovascular events. PMID: 29992830
2. Study shows that the 3'-untranslated region of IGFBP1 mRNA is targeted by miR-542-3p. The results suggest that miR-542-3p plays an important role in endometrial decidualization by regulating the expression of major decidual marker genes. PMID: 28051155
3. we demonstrated that IGFBP-1 suppress the migration of BGC-823 gastric cancer cells and play a protective role in the process of H. pylori-induced gastric cancer. PMID: 28864349
4. hIGFBP1 affects endothelial cell responses and acceleration of endothelial regeneration in transgenic mouse model. PMID: 29186427
5. Vaginal PAMG-1 in patients with a cervical length of 15-30 mm is highly predictive of imminent spontaneous preterm delivery. PMID: 28613021
6. There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors PMID: 27834463
7. A panel consisting of IGFBP1, KIM1, GCLC and GSTM1 genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1, IGFBP3 and KLK1 could be used to monitor progression of CKDu. The regulation of these genes has to be studied on larger populations to validate their efficiency for further clinical use. PMID: 28103909
8. We report interactions between CSNK-2beta and IGFBP-1 as well as mTOR and CSNK-2beta, providing strong evidence of a mechanistic link between mTOR and IGF-I signaling, two critical regulators of cell growth via CSNK-2. PMID: 29037858
9. We conclude that low BDNF and high LCN2 and NF-L levels are associated with Multiple Sclerosis (MS) pathogenesis, and high IGFBP1level is a biomarker for female MS only, suggesting different MS progression pathways between the sexes. LCN2 is a candidate predictor of response to natalizumab treatment, and NF-L is a candidate predictor of clinically isolated syndrome's (CIS) conversion into MS. PMID: 29108879
10. Results show that IGFBP-1 transcription and FoxO1 expression are dysregulated in tamoxifen-resistant cancer cells. PMID: 28096479
11. IGBFBP-1 levels increased significantly in type 2 diabetic patients with acute coronary syndrome on sitagliptin. PMID: 27190088
12. Women with higher IGFBP-1 were more likely to have a low relative muscle mass. PMID: 28732569
13. Levels of serum IGFBP-1 were shown to be significantly higher in patients with NPCs. PMID: 28143425
14. Levels of blood IGFBP-1 in pre- and post-menopausal rheumatoid arthritis patients were significantly higher in comparison to the control group. PMID: 27775453
15. ALDH1A1 and IGFBP1 are differentially overexpressed in CLM and may play a dual role, functioning as both tumor suppressors and metastasis promoters in CRC PMID: 27152521
16. Moreover, a prospective human study showed that having high IGFBP1 levels reduces the risk of developing type-2 diabetes by more than 85%. PMID: 27516442
17. Study provides evidence that elevated values of IGFBP -1 in cervical secretion are highly correlated with preterm labor. PMID: 27452330
18. IGFBP1 levels were higher in patients with multivessel than those with single-vessel lesions; Circulating IGFBP1 level positively correlated with the severity of coronary artery disease. PMID: 28316362
19. The reduced affinity of fibrinogen for IGFBP-1 accompanying diabetes may potentially shift the equilibrium to liberate more IGFBP-1 PMID: 27919172
20. Plasma IGFBP-1 was significantly associated with plasma EPO concentration in acute kidney injury, suggesting an unknown mechanism related to systemic stress conditions for EPO regulation in AKI. PMID: 26479890
21. Results show that fibrinogen forms complexes with IGFBP-1 under physiological conditions. Several experimental approaches have confirmed that complexes are co-isolated with fibrinogen from plasma, they are relatively stable, and they appear as a general feature of human plasma. PMID: 27260393
22. Serum IGFBP-1 and -2 are increased in idiopathic pulmonary fibrosis and IGFBP-2 may be reduced by anti-fibrosing therapy. PMID: 27215343
23. The reference change values values for serum IGFBP-1 were 59.9%, 83.2% and 93.0% and for fasting serum insulin were 68.5%, 79.0% and 93.4% for subjects with normal glucose tolerance, impaired fasting glucose, and impaired glucose tolerance, respectively. PMID: 23548151
24. mTOR inhibition constitutes a mechanistic link between hypoxia, reduced IGF-I bioavailability and fetal growth retardation. PMID: 26714229
25. the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss PMID: 26456333
26. There was a positive correlation between the IGFBP1 levels of and those of inflammatory mediators in HIV Infections. PMID: 25890304
27. trend towards higher cord blood values in intrauterine growth restriction observed PMID: 26118397
28. The amino acid response and mTOR independently regulate IGFBP-1 secretion and phosphorylation in response to decreased amino acid availability. PMID: 25957086
29. Insulin-like growth factor 1 receptor blockade can inhibit glioblastoma growth by different mechanisms, including direct effects on the tumor cells as well as indirect anti-angiogenic effects. PMID: 25543125
30. gene expression analysis of human breast tumors showed that high expression of IGFBP mRNA was strongly correlated with good prognosis but not when MMP9 mRNA was also highly expressed PMID: 26025665
31. study shows up-regulation of MCSF in GBM via a SYK-PI3K-NFkappaB-dependent mechanism and identifies IGFBP1 released by microglial cells as a novel mediator of MCSF-induced angiogenesis PMID: 26245897
32. Activation of IGFBP1 by pregnane X receptor alters the morphology of hepatocellular carcinoma cells and regulates cell migration. PMID: 26232425
33. IGFBP1 in epithelial circulating tumor cells as a potential response marker to selective internal radiation therapy in hepatocellular carcinoma PMID: 25123037
34. Data suggest that expression of IGFBP1 in hepatocytes can be regulated by carnosine, a dietary factor; carnosine down-regulates expression of IGFBP1 in Hep G2 cells; mechanism involves suppression of HIF1A (hypoxia inducible factor 1 alpha subunit). PMID: 25869614
35. Suggest that IGFBP-1 inhibits the invasion and metastasis of HCC cells and that IGFBP-1 may be useful as a valuable marker for the prognosis of patients with HCC. PMID: 25337205
36. Variations in relative quantities of IGFBP-1 monomers and complexes in different tumor types were much more pronounced than those of IGFBP-2. PMID: 25746666
37. term placental explants, but not their conditioned medium, can de-phosphorylate IGFBP-1 through the action of placental alkaline phosphatase PMID: 24856042
38. The predictive value of IGFBP1 in cervical secretion as bedside test for prediction of preterm labor in symptomatic women was studied. PMID: 25597167
39. Data suggest that up-regulation of IGFBP1 in vaginal smears (as a biological marker for presence of amniotic fluid) may be useful point-of-care test for diagnosis of premature rupture of fetal membranes. PMID: 24612210
40. In the second trimester, rapid cervical phIGFBP-1 testing in asymptomatic twin pregnancies has a poor performance in predicting spontaneous preterm delivery PMID: 24436153
41. This paper provides a brief overview of the structure and regulation of IGFBP-rP1 and its various biological functions in cancer--{review} PMID: 24513543
42. DeltaIGFBP-1 as a biomarker of hepatic insulin resistance PMID: 24056811
43. According to this study IGFBP-1 is a specific marker for preterm delivery in pregnant women with clinical symptoms. PMID: 24919336
44. Amniotic fluid samples collected after labour onset contained proteolytic activity that generated 12- and 19-kDa IGFBP-1 fragments that did not bind to 125I-IGF-I. This activity was not detected in amniotic fluid collected prior to labour onset. PMID: 23183724
45. Serum glycodelin levels did not predict endometrial receptivity in patients undergoing in vitro fertilization. PMID: 23585335
46. Pyridoxal may induce the expression of IGFBP1 in hepatoma cells via a mechanism involving the ERK/cJun pathway. PMID: 23942851
47. elevated insulin-like growth factor binding protein 1 appears to be associated with shorter time to castration resistant prostate cancer and lower overall survival in men with metastatic prostate cancer PMID: 24132762
48. C/EBPbeta regulates the expression of IGFBP-1 and PRL by altering the histone acetylation status of their promoters but differently regulates Mn-SOD gene expression in human ESC during decidualization PMID: 24248464
49. The median concentrations of first-trimester vaginal and cervical phIGFBP-1 are higher in women with spontaneous preterm delivery at <32 and <37 weeks gestation. PMID: 23408645
50. FOXO1/IGFBP-1 axis is essential for PRB-dependent growth inhibition of endometrial epithelial cells PMID: 23603247
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亞細胞定位：

Secreted.
數據庫鏈接：

HGNC: 5469

OMIM: 146730

KEGG: hsa:3484

STRING: 9606.ENSP00000275525

UniGene: Hs.642938

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