HAO1 Monoclonal Antibody
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中文名稱：HAO1鼠單克隆抗體
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貨號：CSB-MA080172
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規格：￥1090
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圖片：
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Western blot analysis of 1) Mouse Liver Tissue, 2) Rat Liver Tissue using HAO1 Monoclonal Antibody.
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其他：
產品詳情
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產品描述：HAO1 Monoclonal Antibody（CUSABIO貨號：CSB-MA080172）是針對羥基酸氧化酶1（HAO1）研發的高特異性科研抗體，適用于小鼠和大鼠樣本的ELISA及Western Blot檢測。該抗體采用全長人源重組蛋白作為免疫原制備，具有明確的靶向性，可精準識別HAO1蛋白在代謝通路中的表達變化。HAO1是過氧化物酶體關鍵酶，參與脂肪酸α氧化及電子傳遞過程，對研究肝臟代謝、能量穩態及遺傳性代謝疾病機制具有重要科研價值。產品經嚴格驗證，可穩定應用于細胞裂解液或組織提取物中目標蛋白的定性及半定量分析，為探索脂質代謝調控、氧化應激反應等基礎研究提供可靠工具。本產品適用于生物醫學領域實驗室的分子機制研究、疾病模型構建及藥物靶點篩選等場景，不涉及臨床應用。儲存時建議分裝后置于-20℃環境以保持長期活性，避免反復凍融。
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Uniprot No.：
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基因名：HAO1
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別名：(S) 2 hydroxy acid oxidase antibody; Glycolate oxidase antibody; GOX antibody; GOX1 antibody; HAO1 antibody; HAOX1 antibody; HAOX1_HUMAN antibody; Hydroxyacid oxidase 1 antibody; MGC142225 antibody; MGC142227 antibody; OTTHUMP00000030231 antibody
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宿主：Mouse
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反應種屬：Mouse,Rat
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免疫原：Recombinant Protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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克隆號：10D9
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
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基因功能參考文獻：
- The study presents the first spectroscopic evidence of the formation of an intermediate with absorbance features resembling those of a flavosemiquinone in the oxidative half-reaction of glycolate oxidase. PMID: 21141873
- The inhibitor heteroatoms interact with five active-site residues that have been implicated in catalysis in homologous flavodehydrogenases of L-2-hydroxy acids. In addition, the chlorophenyl substituent is surrounded by nonconserved hydrophobic residues. PMID: 20054120
- These inhibitions suggest that glycolate binds to the active site of the reduced enzyme, and that DCIP also has affinity for the oxidized enzyme. PMID: 17669354
- Active site and loop 4 movements within human glycolate oxidase. PMID: 18215067
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亞細胞定位：Peroxisome.
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蛋白家族：FMN-dependent alpha-hydroxy acid dehydrogenase family
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組織特異性：Liver.
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數據庫鏈接：
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