KCNN4
KCNN4,全稱為Intermediate conductance calcium-activated potassium channel protein 4,常見別名包括SKCa 4、SKCa4、rSK4等。該蛋白屬于鉀離子通道,能夠介導細胞膜上鉀離子的電壓非依賴性轉移。KCNN4蛋白的激活依賴于細胞內鈣離子的濃度增加,其激活后能夠引起細胞膜超極化,進而促進鈣離子的內流。KCNN4蛋白在多種生理過程中發揮重要作用,包括血管收縮、神經細胞興奮性調節、細胞體積穩態維持等。研究表明,KCNN4蛋白與多種疾病密切相關,如高血壓、心律失常、神經退行性疾病等。目前,針對KCNN4蛋白的藥物研發已取得一定進展,例如,有研究開發了一種能夠抑制KCNN4蛋白活性的小分子化合物,該化合物在治療高血壓和心律失常方面展現出良好的前景。此外,KCNN4蛋白還被認為是自身免疫性疾病的潛在治療靶點,相關藥物研發也在進行中。
熱銷產品
驗證數據
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF012086HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) KCNN4.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF012086HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) KCNN4.
KCNN4 Antibody (CSB-PA012086ESR2HU)
驗證數據
Western blot
All lanes: KCNN4 antibody at 8µg/ml + human serum
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa
Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA012086ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA012086ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA012086ESR2HU at dilution of 1:100
KCNN4 Antibodies
KCNN4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012086ESR1HU | KCNN4 Antibody | Human | ELISA, IHC |
| CSB-PA012086ESR2HU | KCNN4 Antibody | Human | ELISA, WB, IHC |
| CSB-PA009613 | KCNN4 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA484256 | KCNN4 Antibody | Human | ELISA,IHC |
| CSB-PA980762 | KCNN4 Antibody | Human,Mouse | ELISA,WB,IHC |
KCNN4 Proteins
KCNN4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012086HU1 CSB-EP012086HU1 CSB-BP012086HU1 CSB-MP012086HU1 CSB-EP012086HU1-B |
Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012086HU | Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4) | in vitro E.coli expression system |
| CSB-MP012086HU | Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)-VLPs | Mammalian cell |
KCNN4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012086MO1 CSB-EP012086MO1 CSB-BP012086MO1 CSB-MP012086MO1 CSB-EP012086MO1-B |
Recombinant Mouse Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012086MO | Recombinant Mouse Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4) | in vitro E.coli expression system |
KCNN4 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP886190RA1 CSB-EP886190RA1 CSB-BP886190RA1 CSB-MP886190RA1 CSB-EP886190RA1-B |
Recombinant Rat Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF886190RA | Recombinant Rat Intermediate conductance calcium-activated potassium channel protein 4 (Kcnn4) | in vitro E.coli expression system |






