GPS2
Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context. Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes.
GPS2 Antibodies
GPS2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA009859GA01HU | GPS2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA008949 | GPS2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA009859LA01HU | GPS2 Antibody | Human | ELISA, IF |
| CSB-PA009859LB01HU | GPS2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA009859LD01HU | GPS2 Antibody, Biotin conjugated | Human | ELISA |
GPS2 Proteins
GPS2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP009859HU CSB-EP009859HU CSB-BP009859HU CSB-MP009859HU CSB-EP009859HU-B |
Recombinant Human G protein pathway suppressor 2 (GPS2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
