肝癌

肝癌是一種發(fā)生在肝臟的惡性腫瘤，主要包括肝細(xì)胞癌（Hepatocellular carcinoma, HCC）、肝內(nèi)膽管癌（Intrahepatic cholangiocarcinoma, ICC）和混合型肝細(xì)胞癌-膽管癌（Combined hepatocellular-cholangiocarcinoma, cHCC-CCA）等類型。

肝癌的發(fā)病原因多樣，常見的風(fēng)險(xiǎn)因素包括乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染、過度飲酒、非酒精性脂肪性肝炎、肝硬化以及其他原因引起的慢性肝病。肝癌的早期癥狀較為隱匿，但隨著病情進(jìn)展，可能出現(xiàn)腹痛、腹部腫脹、黃疸、體重下降等癥狀。

肝癌常用的治療手段包括手術(shù)切除、肝移植、局部消融治療、經(jīng)動(dòng)脈化療栓塞（Transarterial chemoembolization, TACE）、放射治療、系統(tǒng)抗腫瘤治療等。近年來，隨著對(duì)肝癌生物學(xué)認(rèn)識(shí)的深入和治療技術(shù)的進(jìn)步，肝癌的藥物研發(fā)也取得了顯著進(jìn)展，如：

分子靶向治療：多納非尼（Sorafenib）、侖伐替尼（Lenvatinib）等多激酶抑制劑在肝癌治療中顯示出較好的療效，能夠抑制腫瘤生長和血管生成。
免疫治療：免疫檢查點(diǎn)抑制劑如納武利尤單抗（Nivolumab）和帕博利珠單抗（Pembrolizumab）等已在肝癌治療中顯示出潛力，通過激活患者自身的免疫系統(tǒng)來攻擊腫瘤細(xì)胞。
聯(lián)合治療：將免疫治療藥物與血管生成抑制劑或其他藥物聯(lián)合使用，如阿特珠單抗（Atezolizumab）與貝伐珠單抗（Bevacizumab）的聯(lián)合治療，已被證實(shí)能顯著延長患者的生存期。

肝癌藥物靶點(diǎn)

肝癌藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CTLA4
CSB-MP009705HU(M)

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

GPC3
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized human GPC3 (G537R) at 5 μg/ml can bind Anti-GPC3 recombinant antibody, the EC₅₀ is 4.739-7.092 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

TIGIT
CSB-MP675446HU

HFACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155.

MET
CSB-MP013714HU

Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC₅₀ is 2.379-3.094 ng/ml.

ERBB3
CSB-MP007765HU

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC₅₀ is 12.32-15.74 ng/ml.

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	來源	蛋白標(biāo)簽
Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active)	CSB-BP001262HU1	ACVRL1	Baculovirus	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal?10xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	CSB-MP007479HU	EGFR	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active)	CSB-MP007765HU	ERBB3	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Fibroblast growth factor receptor 3 (FGFR3), partial (Active)	CSB-AP003871HU	FGFR3	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Glypican-3 (GPC3), partial (Active)	CSB-AP005371HU	GPC3	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Glypican-3 (GPC3) (G537R), partial (Active)	CSB-MP009705HU(M)	GPC3	Mammalian cell	N-terminal 6xHis-Myc-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005281HU	HAVCR2	Mammalian cell	C-terminal FC-Avi-tagged
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005291HU	HAVCR2	Mammalian cell	C-terminal 6xHis-Fc-tagged
Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial (Active)	CSB-AP005341MO	Havcr2	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Interleukin-15 protein (IL15) (Active)	CSB-AP001621HU	IL15	E.Coli	Tag-Free
Recombinant Human Interleukin-15 (IL15) (Active)	CSB-AP004391HU	IL15	E.coli	Tag-Free

● 穩(wěn)定細(xì)胞株

CT26/Human GPC3 Stable Cell Line

CSB-SC009705HU2

Untransfected CT26 cells (green line) and transfected Human GPC3 CT26 Stable cells (red line) were stained with anti-GPC3 antibody(CSB-RA009705A1HU) (2μg/1*10⁶ cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

TOP1 Recombinant Monoclonal Antibody
CSB-RA792129A0HU

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.

TP53 Recombinant Monoclonal Antibody
CSB-RA024077MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA024077MA1HU (red line) at 1:100.

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	反應(yīng)種屬	應(yīng)用范圍
ACVRL1 Recombinant Monoclonal Antibody	CSB-RA555022A0HU	ACVRL1	Human	ELISA, WB, IHC
ACVRL1 Recombinant Monoclonal Antibody	CSB-RA001262MA1HU	ACVRL1	Human	ELISA
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA1HU	CEACAM5	Human	ELISA
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
EPCAM Recombinant Monoclonal Antibody	CSB-RA932207A0HU	EPCAM	Human	ELISA, WB
EPCAM Recombinant Monoclonal Antibody	CSB-RA439934A0HU	EPCAM	Human	ELISA, WB, IHC
EPCAM Recombinant Monoclonal Antibody	CSB-RA007717MA1HU	EPCAM	Human	ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA

● ELISA試劑盒

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	檢測范圍	靈敏度
Human Alpha-fetoprotein,AFP ELISA Kit	CSB-E04770h	AFP	1.563 ng/mL-100 ng/mL	1.332 ng/mL
Mouse Alpha-fetoprotein,AFP ELISA Kit	CSB-E08282m	AFP	1.23 ng/ml-900 ng/ml.	1.23 ng/ml.
Rat Alpha-fetoprotein,AFP ELISA Kit	CSB-E08281r	AFP	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Pig Alpha-fetoprotein(AFP) ELISA kit	CSB-EL001421PI	AFP	3.12 ng/mL-200 ng/mL	0.78 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human carcinoembryonic antigen,CEA ELISA Kit	CSB-E04767h	CEACAM5	5 ng/mL-120 ng/mL	2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit	CSB-E13925m	CEACAM5	62.5 pg/mL-4000 pg/mL	15.6 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E09171h	CTLA4	125 pg/mL-8000 pg/mL	31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E13637m	CTLA4	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Mouse Protein delta homolog 1(DLK1) ELISA kit	CSB-EL006945MO	DLK1	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Human epidermal growth factor receptor,EGFR ELISA Kit	CSB-E12124h	EGFR	0.312 ng/mL-20 ng/mL	0.019 ng/mL
Human Epithelial cell adhesion molecule(EPCAM) ELISA kit	CSB-EL007717HU	EPCAM	0.625 ng/ml-40 ng/ml	0.156 ng/ml
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit	CSB-E11161h	ERBB2	0.156 ng/mL-10 ng/mL	0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit	CSB-EL007765HU	ERBB3	125 pg/mL-8000 pg/mL	31.25 pg/mL
Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit	CSB-EL008646HU	FGFR3	62.5 pg/mL-4000 pg/mL	15.6 pg/mL
Human Glypican-3,GPC-3 ELISA Kit	CSB-E11333h	GPC3	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Mouse Glypican-3(GPC-3)ELISA Kit	CSB-E15877m	GPC3	3.12 ng/mL-200 ng/mL	0.78 ng/mL