Recombinant Drosophila melanogaster Ubiquitin carboxyl-terminal hydrolase 36 (scny), partial

中文名稱：

黑腹果蠅scny重組蛋白
貨號(hào)：

CSB-YP894266DLU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅scny重組蛋白
貨號(hào)：

CSB-EP894266DLU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅scny重組蛋白
貨號(hào)：

CSB-EP894266DLU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅scny重組蛋白
貨號(hào)：

CSB-BP894266DLU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅scny重組蛋白
貨號(hào)：

CSB-MP894266DLU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

scny
Uniprot No.：

Q9VRP5
別名：

scny; Usp36; CG5505; Ubiquitin carboxyl-terminal hydrolase 36; EC 3.4.19.12; Deubiquitinating enzyme 36; Protein scrawny; Ubiquitin thioesterase 36; Ubiquitin-specific-processing protease 36
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Hydrolase that deubiquitinates polyubiquitinated target proteins including imd. Required for preventing the constitutive activation of the imd/NF-kappa-B (Imd) signaling cascade under unchalleneged conditions. Deubiquitinates imd linked 'Lys-63' chains which leads its proteasomal degradation and consequently down-regulation of the Imd signaling cascade. Removal of the activating 'Lys-63'-linked chains is likely to enable their replacement with 'Lys-48'-linked chains which act as 'tags' the for proteosomal degradation of imd. Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4me3). Controls selective autophagy activation by ubiquitinated proteins.
基因功能參考文獻(xiàn)：
1. specific inactivation in hemocytes renders susceptibility to L. monocytogenes infections PMID: 24777180
2. USP36 controls selective autophagy activation in Drosophila and in human cells. PMID: 22622177
3. The study describes Drosophila ubiquitin protease USP36/Scny function in innate immunity. USP36 is notably required in the gut and prevents constitutive activation of NF-kappaB signal by hydrolysing K63 ubiquitin chains on the adaptator molecule IMD. PMID: 19837371
4. study describes a Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germline, epithelial & intestinal stem cells; it deubiquitylates histone H2B and functions in gene silencing PMID: 19039105
亞細(xì)胞定位：

Nucleus, nucleolus. Cytoplasm.
蛋白家族：

Peptidase C19 family
數(shù)據(jù)庫鏈接：

KEGG: dme:Dmel_CG5505

STRING: 7227.FBpp0076806

UniGene: Dm.6825